OXYCODONE

- Everything we could find out about it

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Created Nov 2020

OXYCODONE

  • [OXYCONTIN]
  • [PERCOCET]
  • [ENDOCET]
  • [ROXICODONE]
  • [ROXICET]

DEA CODE 9143: Schedule 2 Narcotic

About Oxycodone:

  • Oxycodone is an opiate painkiller. It's used to treat severe pain, for example after an operation or a serious injury, or pain from cancer.
  • It's also used for other types of long-standing pain when weaker painkillers, such as paracetamol, ibuprofen and aspirin, have not worked.
  • Oxycodone is only available on prescription. It comes as slow-release tablets, capsules and a liquid which you swallow. It can also be given by an injection, but this is usually done in hospital.
  • Oxycodone is also known by the brand names Oxynorm and OxyContin.
  • It's sometimes given as a tablet which also has a medicine called naloxone in it (Targinact). This is used to prevent certain side effects, such as constipation.

Key Facts:

  • Oxycodone works by stopping pain signals travelling along the nerves to the brain.
  • Oxycodone liquid and capsules work in 30 to 60 minutes but wear off after 4 to 6 hours.
  • It's possible to become addicted to oxycodone, but this is rare if you're taking it to relieve pain and as your doctor has prescribed.
  • Oxycodone can cause withdrawal problems. Do not stop taking the medicine suddenly.
  • The most common side effects of oxycodone are constipation, feeling sick and sleepy.
  • Oxycodone is from a group of medicines called opiates, or narcotics. It works in the central nervous system and the brain to block pain signals to the rest of the body. It also reduces the anxiety and stress caused by pain.

How much will I take?

  • Oxycodone can be taken by adults and children aged 1 month and older.
  • Babies, young children and older people are more likely to get side effects.
  • Oxycodone comes as:
    • capsules - these contain 5mg, 10mg or 20mg of oxycodone
    • slow-release tablets - these contain 5mg, 10mg, 15mg, 20mg, 30mg, 40mg, 60mg, 80mg or 120mg of oxycodone
    • liquid - this contains 5mg of oxycodone in 5ml or 10mg of oxycodone in 1ml of liquid.
  • Oxycodone liquid, capsules and injections work faster (fast acting). They're used for pain which is expected to last for a short time and often used when you start taking oxycodone, to help find the right dose.
  • Oxycodone tablets are slow release. This means the oxycodone is gradually released into your body over either 12 or 24 hours. This type of oxycodone takes longer to start working but lasts longer. It's used for long-term pain.

Do not break, crush, chew or suck oxycodone slow-release tablets. If you do, the slow-release system will not work and the whole dose might get into your body in one go. This could cause an overdose.

Sometimes your doctor may prescribe both fast-acting and slow-release oxycodone to manage long-term pain.


How long does it take to work?

  • Fast-acting oxycodone (capsules and liquid) take 30 to 60 minutes to work, but these wear off after 4 to 6 hours.
  • Slow-acting oxycodone (tablets) can take 1 to 2 days to work fully, but the pain relief will last longer.
  • An oxycodone injection into a vein gives the quickest pain relief and works almost straight away.

What is it?
Semi-synthetic opioid drug prescribed for pain as Tylox, Percodan, OxyContin. Derived from the poppy plant, has high potential for abuse. Oxycodone is a semi-synthetic narcotic analgesic and historically has been a popular drug of abuse among the narcotic abusing population.

What is its origin?
Oxycodone is synthesized from thebaine, a constituent of the poppy plant.

Street Names:
Hillbilly Heroin, Kicker, OC, Ox, Roxy, Perc, Oxy

What does it look like:
Oxycodone is marketed alone as OxyContin in 10, 20, 40 and 80 mg extended-release tablets and other immediate-release capsules like 5 mg OxyIR. It is also marketed in combination products with aspirin such as Percodan or acetaminophen such as Roxicet.

Oxycodone

Oxycodone

How is it used?

  • Pills and tablets chewed or swallowed
  • Inhaling vapors by heating tablet on foil
  • Crushed and sniffed or dissolved in water and injected

How does it affect the body?

  • Feelings of relaxation, euphoria, pain relief
  • Addictive
  • Chronic use of oxycodone with acetaminophen may cause severe liver damage
  • Overdose may lead to coma and possible death.

Drugs that cause similar effects:

OxyContin, a trade name for the narcotic oxycodone hydrochloride, is a painkiller available in the United States only by prescription. OxyContin is legitimately prescribed for relief of moderate to severe pain resulting from injuries, bursitis, neuralgia, arthritis, and cancer. Individuals abuse OxyContin for the euphoric effect it produces - an effect similar to that associated with heroin use.

NDIC PDF Oxycontin

Canada:
Oxycodone is a prescription pain medication - an opioid drug: like morphine, codeine and methadone.

It is found in several products:

  • In combination with other drugs, in products such as Percocet, Oxycocet and Endocet
  • By itself in immediate-release (IR) products, such as Oxy-IR
  • By itself in controlled-release (CR) products, such as OxyContin (no longer available), OxyNEO, Apo-Oxycodone CR and PMS-Oxycodone CR.

OxyContin (also known as "oxy") was developed in 1995 to provide long-lasting pain relief, so people with severe pain would not have to take pills as often.

OxyContin was widely prescribed and became associated with abuse and addiction problems. When the tablet was crushed, the drug released into the body more quickly, which increased its effects.

OxyContin was removed from the Canadian market in 2012 and replaced with OxyNEO, a similar medication that was not so easy to crush. However, when OxyContin's patent expired, similar products were put on the market.

What's the difference between Percocet and oxycodone-CR?
Both Percocet and oxycodone-CR products relieve pain, but while Percocet gives relief for about five hours, the effects of oxycodone-CR last for about 12 hours, when taken as prescribed. Percocet contains five milligrams of oxycodone, which is all released when the pill is taken. Percocet also contains acetaminophen (the drug in Tylenol), which can cause liver damage if you take a lot of it.

Oxycodone-CR products contain only oxycodone. When taken as prescribed, the drug is released over several hours.

In Canada, one oxycodone-CR tablet can contain up to 80 milligrams of oxycodone - the same amount as 16 Percocet tablets.

Usually Swallowed:
Oxycodone comes in a number of forms including capsules, tablets, liquid and suppositories. It also comes in a variety of strengths. Oxycodone is usually swallowed but is sometimes injected or used as a suppository. Some people use oxycodone to become intoxicated, which can result in serious side effects. There is increasing concern among medical professionals about the risks of using these drugs, particularly when they are used for a long time.

To prevent OxyContin tablets being injected, they were reformulated in 2014. The tablets are now resistant to crushing and become a thick gel when added to water.

Opioid Receptors:
Opioids are the strongest form of medication used to treat pain. Opioids work by attaching to opioid receptors, which are found in many areas of the body, including the brain, spinal cord and gastrointestinal tract. An opioid attaches to the receptor, which reduces the transmission of pain messages to the brain, reducing pain. Opioids are used to treat moderate to severe pain that is not well managed with other pain medications. They do not treat the underlying cause of the pain. If cancer is causing the pain, the cancer treatment is aimed at reducing the pain.

Oxycodone Oral Immediate Release Pill (Roxicodone, Percolone):
There are several different formulations of oxycodone. This formulation is a quick acting pill used for the treatment of acute pain. Acute pain is pain that comes on quickly, occurs intermittently, and is sometimes referred to as breakthrough pain. This medication can be used with another medication used to treat chronic pain.

Where do I get this medication?
Oxycodone pills are available through retail and mail order pharmacy. Your oncology team will work with your prescription drug plan to identify an in-network retail/mail order pharmacy for medication distribution. Mail order delivery must be hand delivered and signed for. This medication cannot be "called in" or electronically prescribed to your local pharmacy; you must provide the original prescription to the pharmacist. Many pharmacies do not keep this medication in stock, but will order it for you.

There may be a delay in availability, so plan prescription refills accordingly.

What are the uses for oxycodone?
Oxycodone is prescribed for the management of pain severe enough to require daily, around-the-clock, long-term treatment with a narcotic, and for which alternative treatment options are inadequate for the relief of moderate to severe pain.

Oxycodone does not eliminate the sensation of pain but decreases discomfort by increasing the tolerance to pain.

In addition to tolerance to pain, oxycodone also causes sedation and depression of respiration. Oxycodone (brand names OxyContin, Roxicodone, Oxecta, Oxaydo, Xtampza ER, Roxybond) is a narcotic pain-reliever prescribed for moderate to moderately severe pain. Some side effects include lightheadedness, dizziness, sedation, nausea, vomiting, drowsiness, and constipation. Drug interactions, dosing, and pregnancy and breastfeeding information should be reviewed prior to taking this medication.

The FDA approved oxycodone in 1976.

Brands:

Oxycodone:
Is the powerful primary ingredient in many painkillers prescribed to people suffering from moderate to severe pain. These pills come in various shapes, sizes and colors depending on the dose and brand. Oxycodone is also sometimes prescribed in a liquid form. It is often prescribed as a combination product with other drugs, including acetaminophen aspirin, and ibuprofen, with different brand names depending on the combination.

Oxycodone, as found in OxyContin or Percocet, is a powerful painkiller and one of the most commonly abused prescription drugs in the country.

Some of the most common brand names for oxycodone-based drugs are:

OxyContin:
One of the most commonly abused prescription drugs. The drug's controlled-release formula provides chronic pain relief for up to 12 hours. Many people bypass the time-release action by crushing and snorting OxyContin, or by dissolving the tablets in water and injecting the solution. This allows the user to achieve the full effect of the drug all at once.

Percocet:
A combination of oxycodone and acetaminophen (the active ingredient in Tylenol). It is commonly prescribed for a number of conditions with pain ranging from mild to severe. Similar to OxyContin, crushing and snorting Percocet is a common method of abuse. Other modes of abuse include taking more than the prescribed Percocet dosage, taking the drug for longer than the prescribed period of time, and chewing or injecting Percocet.

Roxicodone:
A rapid release formula of oxycodone that is used to treat moderate to severe pain. It is often given to a patient before surgery to sedate or calm them and for around-the-clock pain management. When abused, the drug causes a very quick high in the user. People who abuse Roxicodone often crush or melt down the tablets to be smoked or injected.

Alcohol and benzodiazepines are two of the most dangerous substances to combine with oxycodone. Because oxycodone, alcohol, and benzos all depress the central nervous system, mixing them can be extremely damaging, and potentially fatal. This deadly cocktail can slow down breathing and cardiac function to the point of complete failure. Even if the combination doesn't cause death, it can cause irreversible damage to the brain and major organs.

In 2011, Oxycodone (Oxycontin) considered the number one opioid killer due to overdose deaths as reported by the U.S. Centers for Disease and Control (CDC) (In 2011, oxycodone ranked first. From 2012 to 2015, it was heroin, and in 2016, fentanyl. Cocaine consistently was the second or third drug most common in overdoses during the entire period.)


Oxycodone is a semisynthetic opioid used for the management of acute and chronic pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. After oxycodone binds to the MOR, a G protein-complex is released, which inhibits the release of neurotransmitters by the cell by reducing the amount of cAMP produced, closing calcium channels, and opening potassium channels. After a dose of conventional (instant-release) oral oxycodone, the onset of action is 10 - 30 minutes, and peak plasma levels of the drug are attained within roughly 30 - 60 minutes in contrast, after a dose of OxyContin (an oral controlled-release formulation), peak plasma levels of oxycodone occur in about three hours. The duration of instant-release oxycodone is 3 to 6 hours, although this can be variable depending on the individual. Oxycodone in the blood is distributed to skeletal muscle, liver, intestinal tract, lungs, spleen, and brain. Serious side effects of oxycodone include reduced sensitivity to pain (beyond the pain the drug is taken to reduce), euphoria, anxiolysis, feelings of relaxation, and respiratory depression. Common side effects of oxycodone include constipation (23%), nausea (23%), vomiting (12%), somnolence (23%), dizziness (13%), itching (13%), dry mouth (6%), and sweating (5%).

How long does it take to wear off?
If you've been prescribed oxycodone, you may be curious as to how long the effects will last in your body, and how long the medication may show up on a drug test. Oxycodone is taken by mouth (oral) and should be taken with food. You should start feeling the effects of oxycodone in just 20 to 30 minutes.

Over time, you may build up a tolerance to oxycodone.

Oxycodone reaches peak concentrations in the bloodstream in roughly one to two hours following ingestion. Immediate-release formulations of oxycodone have average half-life of 3.2 hours.

it takes 3.2 hours for the average person to eliminate half of the dose of oxycodone

It takes several half-lives to fully eliminate a drug. Since everyone metabolizes medications differently, the half-life will vary from person to person. For most people, oxycodone will fully clear the blood within 24 hours, but it can still be detected in the saliva, urine, or hair for longer than that.

Oxycodone can be detected in:

  • Saliva: for one to four days after the last dose is taken
  • Urine: for three to four days after the last dose is taken
  • Hair: for up to 90 days after the last dose is taken
You will likely stop "feeling" the pain relief of oxycodone long before it fully clears your body. This is why your doctor may have you take a single tablet of oxycodone every four to six hours while you're in pain.

Oxycodone
Duration:

A semisynthetic opioid analgesic developed in 1917, prescribed primarily for pain management. It has become extremely popular as a recreational drug in some areas, and carries a high potential for addiction. Reported as being a little more 'stimulating' than other opioids.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
Oral_IR:20 minutes4-6 hours1-24 hours
Oral_ER:40 minutes6-8 hours1-24 hours
Insufflated:2-5 minutes3-5 hours1-24 hours
IV:0-1 minutes3-5 hours1-24 hours
Oxycodone Duration
Avoid:
Grapefruit juice, alcohol, and diphenhydramine. These products may react negatively and cause an overdose. Also do not consume more than 4g APAP (acetaminophen) in a day.
Detection:
3-5 days for minimal use, 5-8 for regular use.
Aliases:
  • Oxy
  • Oxycontin
  • Percocet
  • Oxynorm
Marquis:
Pale violet
Half Life:
2-4 hours
Effects:
Pain relief, Respiratory depression, Sedation, Constipation, Cough suppression, Decreased libido, Difficulty urinating, Itchiness, Nausea, Pupil constriction, Stomach cramps, Appetite suppression, Euphoria, Anxiety suppression, Dream potentiation.

Oxycodone drug usage

52nd most prescribed medicine in the United States for 2017

Drug Abusers Prefer Oxycodone:
A nationwide survey of opioid drug abusers in rehab indicates that because of the high it produces, the prescription painkiller oxycodone is the most popular drug of choice. Hydrocodone, also prescribed to treat pain, is next in line. In all, some 75 percent of those surveyed rated one of these drugs as their favorite. Researchers at Washington University School of Medicine in St. Louis and Nova Southeastern University in Miami questioned more than 3,500 people in 160 drug-treatment programs across the United States, asking which drugs they abuse and why. Oxycodone was favored by 45 percent, and hydrocodone was preferred by about 30 percent.

Although the drugs are meant to be taken orally, almost 64 percent of oxycodone abusers and just over one-quarter of hydrocodone abusers crushed the tablets and inhaled the drug, while one in five oxycodone abusers reported that they sometimes dissolved the drug in water and injected it. Less than 5 percent reported taking hydrocodone intravenously.

Personality, age and gender all played a role in drug preferences, the research showed. Oxycodone was attractive to those who enjoy taking risks and prefer to inject or snort drugs to get high. Young, male drug users tend to fit that profile. In contrast, hydrocodone is the more popular choice among women, older people, people who don't want to inject drugs and those who prefer to deal with a doctor or friend rather than a drug dealer.

Oxycodone Abuse in the United States:
The potential for abuse of oxycodone is immense, and it has been problematic for a long time. The drug first became available in 1916. It only took a year before its first use as a drug, although it took until 1939 for oxycodone to make it to the United States market. Oxycodone didn't start to make waves for several years, but when it did become clear that abuse and addiction were problems, the World Health Organization stepped up, introducing the concept of opioid dependence in 1964.

1990 saw the seeds of today's opioid crisis planted when the use of these powerful painkillers extended from treating cancer patients to treating those with non-cancer pain. The Joint Commission on Accreditation of Healthcare Organizations claimed, "There is no evidence that addiction is a significant issue when persons are given opioids for pain control." We now know this statement, backed by the for-profit makers of OxyContin, was patently false.

Today, 35% of all opioid overdose deaths are due to prescription painkillers. Oxycodone, especially in the form of OxyContin, is one of the top three drugs most commonly involved in overdose deaths. Total prescription opioid deaths have more than quadrupled since 1999, even though Americans have not been reporting more pain.

There have been multiple initiatives meant to curb the prescription of opioids like OxyContin and Percocet so patients can't get enough of the drug to abuse it. CVS is now limiting most of its new opioid prescriptions to a seven-day supply, and Cigna announced it would begin directing patients to equivalents with abuse-deterrent properties instead of covering most OxyContin prescriptions.

Mixing Alcohol and Oxycodone:
On May 13, 2011, professional hockey player Derek Boogaard died in Minneapolis. The cause of his death was an overdose on a combination of oxycodone and alcohol. After his death, his family revealed that he had been struggling with addiction for several years. Derek's death was tragic, but it was not unusual. Thousands of Americans die every year from overdosing on oxycodone and other opioids. Oxycodone is one of the most common contributors to fatal overdoses on prescription opioids in the United States. Alcohol increases the dangers of oxycodone. In fact, mixing the two substances, even accidentally, may cost someone their life.

Combining alcohol with oxycodone is highly dangerous. Both drugs function as central nervous system depressants. Alcohol, like opioids, slows down a person's breathing. When the body attempts to withstand the effects of both drugs, the respiratory system may be overwhelmed. In fact, the combination of alcohol and oxycodone is likely to cause respiratory depression, a condition characterized by minimal breathing or no breathing at all. This is a form of suffocation. If left untreated, respiratory depression can quickly cause brain damage and ultimately cause someone to die.

Researchers have found that drinking even a moderate amount of alcohol along with taking just one oxycodone pill is enough to risk respiratory depression. Studies have also shown that the elderly are most vulnerable to having a fatal oxycodone overdose after drinking alcohol. The combination of the two drugs also endangers the heart. Since they are depressants, alcohol and oxycodone both slow down a person's heart rate. For this reason, mixing alcohol and oxycodone may shock the cardiovascular system and cause a heart attack or a stroke.

Since neither alcohol nor oxycodone (as prescribed medication) are illegal, it's easy for normal, law-abiding people who have no experience with using drugs to take them both in a single day, possibly without understanding how dangerous they are together.

OxyContin (oxycodone hydrochloride)
Maximum Dosage:
Prescribers Digital Reference
Adults:Immediate-release dosage forms, extended-release tablets: There is no maximum dose of oxycodone; however, careful titration of oxycodone, especially in opiate-naive patients, is required until tolerance develops to some of the side effects (i.e., drowsiness and respiratory depression). Individualize dosage carefully.
Extended-release capsules (Xtampza ER): 288 mg/day PO (equivalent to 320 mg/day oxycodone hydrochloride).
Geriatric:Immediate-release dosage forms, extended-release tablets: There is no maximum dose of oxycodone; however, careful titration of oxycodone, especially in opiate-naive patients, is required until tolerance develops to some of the side effects (i.e., drowsiness and respiratory depression). Individualize dosage carefully.
Extended-release capsules (Xtampza ER): 288 mg/day PO (equivalent to 320 mg/day oxycodone hydrochloride).
Adolescents:Extended-release tablets: With appropriate dosage titration, there is no maximum dose of extended-release oxycodone in opioid-tolerant pediatric patients; however, careful titration is required until tolerance develops to some of the side effects (i.e., drowsiness and respiratory depression). Individualize dosage carefully.
Immediate-release dosage forms and extended-release capsules (Xtampza ER): Safety and efficacy have not been established.
Children:Extended-release tablets in Children 11 years or older: With appropriate dosage titration, there is no maximum dose of extended-release oxycodone in opioid-tolerant pediatric patients; however, careful titration is required until tolerance develops to some of the side effects (i.e., drowsiness and respiratory depression). Individualize dosage carefully.
Children:Extended-release tablets in Children younger than 11 years, immediate-release dosage forms, and extended-release capsules (Xtampza ER): Safety and efficacy have not been established.
Infants:Safety and efficacy have not been established.
Neonates:Safety and efficacy have not been established.

Prescribed for:

  • Severe chronic pain with opioid tolerance
  • Severe chronic pain in opioid-tolerant pediatric patient (11 years of age and older)
  • Severe chronic pain requiring long-term opioid treatment
  • Pain
  • Severe pain with opioid tolerance
Uses:
This medication is used to help relieve moderate to severe pain. Oxycodone belongs to a class of drugs known as opioid analgesics. It works in the brain to change how your body feels and responds to pain.

Before using:
Tell your doctor or pharmacist your medical history, especially of:

  • Brain disorders (such as head injury, tumor, seizures)
  • Breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease-COPD)
  • Kidney disease
  • Liver disease
  • Mental/mood disorders (such as confusion, depression)
  • Personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol)
  • Stomach/intestinal problems (such as blockage, constipation, diarrhea due to infection, paralytic ileus)
  • Difficulty urinating (such as due to enlarged prostate)
  • Gallbladder disease
  • Disease of the pancreas (pancreatitis)

Precautions:

  • This drug may make you dizzy or drowsy.
  • Alcohol or marijuana (cannabis) can make you more dizzy or drowsy.
  • Do not drive, use machinery, or do anything that needs alertness until you can do it safely.
  • Avoid alcoholic beverages.
  • Talk to your doctor if you are using marijuana (cannabis).

WARNINGS:

Oxycodone has a risk for abuse and addiction, which can lead to overdose and death.

Oxycodone may also cause severe, possibly fatal, breathing problems.

To lower your risk, your doctor should have you take the smallest dose of oxycodone that works, and take it for the shortest possible time.

The risk for severe breathing problems is higher when you start this medication and after a dose increase, or if you take the wrong dose/strength.

Taking this medication with alcohol or other drugs that can cause drowsiness or breathing problems may cause very serious side effects, including death.

Also, other medications can affect the removal of oxycodone from your body, which may affect how oxycodone works. Be sure you know how to take oxycodone and what other drugs you should avoid taking with it.

Get medical help right away if any of these very serious side effects occur: slow/shallow breathing, unusual lightheadedness, severe drowsiness/dizziness, difficulty waking up.

User Reviews:

1977 Total User Reviews
Oxycodone Oral:
Read Reviews
Condition: Pain (1451 Reviews):
Effectiveness(3.89)

Ease of Use(4.35)

Satisfaction(3.71)

Pediatric:
Appropriate studies have not been performed on the relationship of age to the effects of Oxaydo, Roxicodone, Roxybond, and Xtampza ER in the pediatric population.

Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Oxycontin in children. However, safety and efficacy have not been established in children younger than 11 years of age.

Geriatric:
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxycodone in the elderly. However, elderly patients are more likely to have age-related liver, kidney, heart, or lung problems, which may require caution and an adjustment in the dose for patients receiving oxycodone in order to avoid potentially serious side effects.

Other Interactions:

  • Ethanol
  • Grapefruit Juice

Other Medical Problems:
Make sure you tell your doctor if you have any other medical problems, especially:

  • Addison disease (adrenal gland problem)
  • Alcohol abuse, or history of
  • Brain tumor, history of
  • Breathing or lung problems (eg, hypoxia, COPD, sleep apnea)
  • Cancer of the esophagus or colon
  • Central nervous system (CNS) depression
  • Cor pulmonale (serious heart condition)
  • Drug dependence, especially with narcotics, or history of
  • Enlarged prostate (eg, BPH, prostatic hypertrophy)
  • Gallbladder disease or gallstones
  • Head injuries, history of
  • Hypothyroidism (an underactive thyroid)
  • Hypovolemia (low blood volume)
  • Kyphoscoliosis (curvature of the spine with breathing problems)
  • Problems with passing urine
  • Psychosis (mental disease)
  • Stomach or bowel problems (eg, esophageal or colon cancer with a small gastrointestinal lumen)
  • Trouble swallowing
  • Weakened physical condition - Use with caution. May increase risk for more serious side effects
  • Asthma, acute or severe
  • Respiratory depression (serious breathing problem)
  • Stomach or bowel blockage (including paralytic ileus) - Should not be used in patients with these conditions
  • Hypotension (low blood pressure)
  • Pancreatitis (swelling of the pancreas)
  • Seizures, history of - Use with caution. May make these conditions worse
  • Kidney disease, severe
  • Liver disease - Use with caution. The effects may be increased because of slower removal of the medicine from the body

Important Information:
You should not use oxycodone if you have severe asthma or breathing problems, or a blockage in your stomach or intestines.

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Taking oxycodone during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

Oxycodone can slow or stop your breathing. This is more likely in elderly or ill patients, but can occur in anyone taking this medicine.

Do not drink alcohol. Dangerous side effects or death could occur.

Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Avoid medication errors. Always check the brand and strength of oxycodone you get from the pharmacy.

Interactions:

Drug Interactions (523) Alcohol/Food Interactions (1) Disease Interactions (17)


What other drugs will affect Oxycodone?
You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C. Opioid medication can interact with many other drugs and cause dangerous side effects or death.

Be sure your doctor knows if you also use:

  • other narcotic medications - opioid pain medicine or prescription cough medicine
  • sedative medications including:
  • sleeping pills
  • muscle relaxants or tranquilizers
  • medicine for depression, anxiety, or other mental illness
  • medicine for Parkinson's disease
  • migraine headache treatment
  • medications used for the prevention of nausea and vomiting
  • cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic ("water pill")
  • medicines for motion sickness, irritable bowel syndrome, or overactive bladder
This list is not complete and many other drugs may interact with oxycodone.

A total of 523 drugs are known to interact with Oxycodone.

  • 193 major drug interactions
  • 329 moderate drug interactions
  • 1 minor drug interactions

Breastfeeding:

Summary of Use During Lactation:
Other agents are preferred over oxycodone during breastfeeding.

Alternate Drugs to Consider:

Oxycodone with Acetaminophen:
Do not take with other acetaminophen medicines. This pain reliever has two active ingredients: oxycodone and acetaminophen (also known as Tylenol, and often abbreviated as APAP). Too much acetaminophen can damage the liver and cause death. While taking oxycodone with acetaminophen, do not take nonprescription acetaminophen or other medicines that contain acetaminophen, including many cold medicines. Adults should not take more than 3,000 to 4,000 mg of acetaminophen each day. Depending on what your doctor prescribed, each tablet or liquid dose of this medicine contains between 300 mg and 650 mg of acetaminophen.

ISMP PDF Oxycodone

IMPORTANT WARNING:
Oxycodone may be habit-forming. Take oxycodone exactly as directed. Do not take more of it, take it more often, or take it in a different way than directed by your doctor. While taking oxycodone, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse oxycodone if you have or have ever had any of these conditions. Talk to your healthcare provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.

Oxycodone may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take oxycodone. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways), a head injury or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.

Taking certain other medications with oxycodone may increase the risk of serious or life-threatening breathing problems, sedation, or coma. Tell your doctor and pharmacist if you are taking or plan to take any of the following medications:

12 Hour Problem:
The drugmaker Purdue Pharma launched OxyContin two decades ago with a bold marketing claim: One dose relieves pain for 12 hours, more than twice as long as generic medications. Patients would no longer have to wake up in the middle of the night to take their pills, Purdue told doctors. One OxyContin tablet in the morning and one before bed would provide "smooth and sustained pain control all day and all night."

On the strength of that promise, OxyContin became America's bestselling painkiller, and Purdue reaped $31 billion in revenue.

Oxycontin Sales

But OxyContin's stunning success masked a fundamental problem: The drug wears off hours early in many people, a Los Angeles Times investigation found. OxyContin is a chemical cousin of heroin, and when it doesn't last, patients can experience excruciating symptoms of withdrawal, including an intense craving for the drug.

The problem offers new insight into why so many people have become addicted to OxyContin, one of the most abused pharmaceuticals in U.S. history.

FDA PDF Oxycodone

EMC PDF Oxycodone

Medsafe PDF Oxycodone

Caymanchem PDF Oxycodone

  
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