MDMA

- Everything we could find out about it

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Created Sep 2019 | Updated Nov 2020

MDMA

  • [ECSTASY]
  • [XTC]
  • [MOLLY]
  • [NEXUS]

3,4-METHYLENEDIOXYMETHAMPHETAMINE

DEA CODE 7405: Schedule 1

MDMA (also known as ecstasy) is a synthetic (man-made) drug that causes both hallucinogenic and stimulant effects. The drug was developed in Germany in the early twentieth century as an appetite suppressant, but today's users consume the drug for its hallucinogenic effects, which they claim heighten their senses and make them feel less inhibited. Users also consume MDMA for its stimulant properties, which enable them to dance for hours at all-night parties and nightclubs.

NDIC PDF MDMA

10 Facts About MDMA:

  1. MDMA, often referred to as "ecstasy" or "molly", is short for 3,4 methylenedioxymethamphetamine, a psychoactive drug derived from safrole oil. MDMA produces effects that resemble both stimulants and psychedelics, as well as its signature effect: a feeling of connectedness.
  2. People who use MDMA describe themselves as feeling euphoric, open, accepting, unafraid, and connected to those around them. Typically used in social settings like festivals, concerts and clubs, MDMA's effects are stimulated by visuals, sounds, smells and touch, leading to heightened sensations and a desire to intensify these feelings by dancing, talking and touching.
  3. MDMA is the official scientific name for this drug. "Molly" and "ecstasy" are both commonly used slang terms. However, since MDMA is currently illegal and therefore unregulated, anything sold as "molly" or "ecstasy" could range from being pure MDMA, to being cut with other drugs, to containing no MDMA at all. The molly market is one of the most adulterated illicit drug markets, meaning it often is cut with other substances.
  4. Since MDMA is currently illegal and therefore not regulated, it is very difficult for an individual user to be 100% certain what's in any given dose. There are personal drug checking kits, which use liquid chemical reagents to help potential users get a better understanding of what's in their substance. These kits come with a color chart that helps people determine what drug (if any) is mostly present in the substance they've tested. Users should also know that these kits, while not considered illegal under federal laws, can be considered drug paraphernalia depending on how a state's law is written.
  5. "Overdose" refers to taking a higher than appropriate dose of a medicine or drug, which can happen with MDMA, but is extremely rare. It is much more likely that a problem would occur as a result of MDMA use with contraindicated medications (such as MAOI anti-depressants), preexisting health conditions, overexertion, or dehydration. Given the highly adulterated molly market, it's also more likely to see an unidentified substance cause problems, rather than MDMA itself. Hyperthermia - a dangerously high increase in body temperature, or heatstroke - is the most common health problem related to MDMA. Hyperthermic reactions result from physical exertion (such as dancing) in an overheated environment without replenishing fluids, which is why it is strongly recommended that users take breaks and consume fluids such as water or electrolyte-replenishing drinks. In extreme cases, hyperthermia can cause liver, kidney or heart failure, or even death. Another concern for people who take MDMA is hyponatremia - drinking too much water. This causes the sodium in the blood to dilute to critically low levels, and seems to affect women more than men. This is why, when available, juices and electrolyte replenishing drinks are preferable to water.
  6. As with all alcohol and other drug use, taking MDMA carries risks, albeit comparatively lower than most other drugs. A 2010 study published in the prestigious Lancet journal was conducted to gauge the relative potential harms of drugs to both consumers and to society, and MDMA was found to be among the least risky.
  7. Due to being one of the most adulterated drug markets, the impurity of molly in different regions and at different times varies quite a bit - that is, there's no such thing as the "most common adulterants." Besides MDMA, "ecstasy" or "molly" may contain varying levels of:
    • Psychoactive substances designed to mimic the effects of MDMA like MDA (methylene-dioxyamphetamine a.k.a. "sass") or "bath salts" (a general term for synthetic cathinones, a class of amphetamine-like stimulants);
    • Stimulants like amphetamine, cocaine, caffeine or methamphetamine; or, more rarely
    • Anesthetics such as ketamine ("Special K") or dextromethorphan (DXM - an ingredient found in over-the-counter cough medicines).
  8. The long-term health impacts of MDMA are still under investigation, but several studies have found that substances like MDMA have far lower potential to cause harm than legal drugs like alcohol. Some researchers suggest that slight brain changes may result from heavy use, such as impacts on memory, but the evidence is far from conclusive. In fact, MDMA use alone does not appear to cause cognitive differences between people who use it and those who do not. Evidence also shows that "adverse effects decrease with abstinence" (that is, the impacts start reversing themselves once you stop taking the drug). The main challenge of determining long-term health effects of MDMA is that people who use it often take other drugs as well, making specific impacts very hard to isolate.
  9. Among the general population, MDMA use is not very common. According to the 2013 National Survey on Drug Use and Health, only 0.3 percent of people aged 12 and older reported using "ecstasy" in the past month, 1 percent reported using it in the past year, and 6.8 percent reported using at least once in their lifetime. A significant portion of this drug's use, especially among young people, takes place in nightlife and festival settings. Nearly 80,000 young adults around the world who use drugs were surveyed for the Global Drugs Survey in 2014. Among this sample - over 50 percent of whom reported going "clubbing" at least four times per year - MDMA was in the top five drugs used in the past year. More than 20 percent of U.S. respondents reported using MDMA in the past year.
  10. Before MDMA became popular at festivals, concerts, clubs and raves, it was indeed utilized for therapeutic purposes among mental health practitioners. MDMA-assisted therapy combines traditional psychotherapy with the administration of MDMA. Because of MDMA's unique effect of reducing fear and enhancing interpersonal trust, it can be especially helpful in healing psychological and emotional damage from traumas, helping the terminally ill face death, and other difficult to treat psychological conditions.

Ecstasy or MDMA

Ecstasy or MDMA
(also known as Molly)

In theory: Molly is uncut MDMA.
Ecstacy = MDMA that has been cut with filler ingredients (like caffeine)

  • A synthetic drug that alters mood and perception (awareness of surrounding objects and conditions). It is chemically similar to both stimulants and hallucinogens, producing feelings of increased energy, pleasure, emotional warmth, and distorted sensory and time perception.
  • MDMA was initially popular in the nightclub scene and at all-night dance parties (raves), but the drug now affects a broader range of people who more commonly call the drug Ecstasy or Molly.
  • People who use MDMA typically take it as a capsule or tablet. Many people take it in combination with other drugs.
  • MDMA acts by increasing the activity of three brain chemicals: dopamine, norepinephrine, and serotonin.
  • Effects include increased energy, distorted perception, involuntary teeth clenching, dangerously high body temperature, and depression.
  • Many people are unaware that Ecstasy and supposedly "pure" Molly also often contain not only pure MDMA but other drugs that may be particularly dangerous when mixed with MDMA.
  • Research results vary on whether MDMA is addictive. Some people report signs of addiction.
  • Some people seeking treatment for MDMA addiction have found behavioral therapy to be helpful. There are no specific medical treatments for MDMA addiction.

What is MDMA?
MDMA is a synthetic, psychoactive drug with a chemical structure similar to the stimulant methamphetamine and the hallucinogen mescaline.

MDMA is an illegal drug;
It acts as both a stimulant and psychedelic, producing an energizing effect, as well as distortions in time and perception and enhanced enjoyment from tactile experiences. It is known commonly as Ecstasy and Molly. This illicit drug exerts its primary effects in the brain on neurons that use the chemicals serotonin, dopamine and norepinephrine to communicate with other neurons.

Serotonin is most likely responsible for the feelings of empathy, elevated mood, and emotional closeness experienced with this drug. Overall, these neurotransmitter systems play an important role in regulating: mood, energy/activity and the reward system, appetite, aggression, sexual activity, sleep, sensitivity to pain, heart rate, blood pressure.

Street drug since the 1980s:
MDMA was first synthesized by a German company in 1912, possibly to be used as an appetite suppressant. It has been available as a street drug since the 1980s, and use escalated in the 1990s among college students and young adults. Then, it was most often distributed at late-night parties called "raves", nightclubs, and rock concerts. As the rave and club scene expanded to metropolitan and suburban areas across the country, MDMA use and distribution increased as well. MDMA is frequently used in combination with other drugs. Today, the drug is still used by a broader group of people who more commonly call it Ecstasy or Molly.

Addiction:
Is MDMA (Ecstasy/Molly) addictive?
Research results are controversial on whether MDMA can be addictive. Some people do report signs and symptoms of addiction. Almost 60% of people who use Ecstasy report some withdrawal symptoms, including fatigue, loss of appetite, depressed feelings, and trouble concentrating.

There are no specific treatments for MDMA addiction. Therapy is typically directed by a substance use clinic or health care provider and involve supportive care and behavioral and group therapy.

What are the effects of MDMA?
A person may experience the intoxicating effects of MDMA within 45 minutes or so after taking a single dose. Those effects include an enhanced sense of well-being, increased extroversion, emotional warmth, empathy toward others, and a willingness to discuss emotionally charged memories. In addition, people report enhanced sensory perception as a hallmark of the MDMA experience.

Use of even moderate doses of MDMA in crowded, warm environments - or during periods of vigorous, extended physical activity - can dramatically increase body temperature, with potential deadly consequences.

However, MDMA can also cause a number of acute adverse health effects. For example, while fatal overdoses on MDMA are rare, they can potentially be life threatening - with symptoms including high blood pressure (hypertension), faintness, panic attacks, and in severe cases, a loss of consciousness and seizures.

MDMA History:
German chemists originally synthesized MDMA, or ecstasy, for pharmaceutical purposes in 1912. During the Cold War, the CIA experimented with MDMA as a psychological weapon. Ecstasy had become a popular party drug by the late 1980s. Despite the illicit drug's legal status, some medical researchers now believe MDMA could have therapeutic benefits, particularly among people with PTSD, depression and other behavioral issues.

Discovered 1912:
German chemists discovered 3,4-methylenedioxymethamphetamine, or MDMA, in 1912 while developing other medicines that could stop bleeding.

1950s:
During the Cold War both the U.S. Army and the CIA experimented with MDMA and other hallucinogenic drugs as weapons. The CIA experimented with MDMA as part of MK-Ultra, but only tested the drug on non-human subjects. These experiments produced the first known toxicology studies of MDMA. The drug's code name was EA-1475.

1970s:
In the 1970s, some psychiatrists began using MDMA as a psychotherapeutic tool.They thought it made their patients more willing to communicate and participate in the psychotherapy process. Therapists called the drug "Adam," because they felt it returned patients to a more innocent state.

1980s:
But by the 1980s, ecstasy or molly had become more widely known as a party drug. In a 1984 article, the San Francisco Chronicle called the drug "the yuppie psychedelic," because it was supposedly milder and less dangerous than LSD.

1985:
In 1985, as part of the "War on Drugs," the United States outlawed MDMA under the Controlled Substances Act as a Schedule 1 drug.

2000s -
Since the mid-2000s, there have been several ecstasy-related deaths at high-profile electronic dance music festivals, including Electric Daisy Carnival and Electric Zoo. Many of these deaths have been attributed to the drug's ability to cause overheating.

Ecstasy also raises core body temperature. The drug can interfere with a user's ability to tell they're becoming overheated. The risk of ecstasy deaths increases in hot environments such as crowded nightclubs or outdoor music venues, yet even at normal temperatures, ecstasy can kill by overheating the body.


Methylenedioxymethamphetamine (or 3,4-methylenedioxymethamphetamine (MDMA)), a synthetic, psychoactive drug also known as ecstasy that was used as a recreational drug. This drug acts as both a stimulant and psychedelic and exerts its effects in the brain on neurons that use the chemicals serotonin, dopamine and norepinephrine to communicate with other neurons. In spite of the presence of this compound in the List of control and forbidden compounds, it was studied in psychotherapy for patients with chronic, treatment-resistant posttraumatic stress disorder. Initial results showed efficacy for the treatment approach, although further studies are needed.

MDMA Also called:
Dizzle, Xtc, Superman, Rolexs, Pink Superman, Pills, Mitsubishis, Mandy, E, Dolphins, Crystal, Cowies, Brownies, Molly, Beans, MD

Ecstasy (MDMA) is a dissociative hallucinogenic compound that produces exhilaration, sedation, hallucinations (seeing, hearing, or experiencing things in other sensory modalities that do really exist in reality), and feelings of dissociation (feeling as if one is not connected to their body, as if one is not real, or as if things are not real). The effects of the drug are dose-dependent, and at low doses, there may be more stimulant effects whereas at higher doses, there may be more hallucinogenic and dissociative effects.

Ecstasy is a synthetic drug. This means it is made by people in a lab and doesn't come straight from a plant like many other drugs do. It is both a stimulant and a hallucinogenic drug that changes the way the user thinks, acts, and feels by interacting with sensory and time perception as well as emotions. It can make a person feel emotionally close to others.

Heart rate, blood pressure, breathing, and body temperature all go up when ecstasy is taken. As it is often taken at parties, clubs, and raves where people are pressed together and dancing, it can cause temperature to get dangerously high very quickly, which can be deadly, leading to heart, kidney, or liver failure.

Ecstasy is also manmade illegally, and you may never know what is actually in the drug that you are buying and taking. It may be "cut" with other things to stretch out the product so drug makers and dealers can get more profit from it. Every dose of ecstasy may be different, and it can be nearly impossible to predict how the drug will react in your body as you don't actually know what might be in the product you are taking. Overdose is a real risk, especially if ecstasy is taken with other drugs or alcohol, which is common.

The "crash" after ecstasy wears off, which takes place 3-6 hours after taking it, can last for several days.

MDMA acts as both a stimulant and psychedelic, producing an energizing effect, distortions in time and perception, and enhanced enjoyment of tactile experiences. It is used to reduce inhibitions. MDMA produces both amphetamine like stimulation and mild mescaline like hallucinations.

Although MDMA is known among users as ecstasy, researchers have determined that many ecstasy tablets contain not only MDMA but also a number of other drugs or drug combinations that can be harmful, such as:
Methamphetamine, ketamine, cocaine, the over-the-counter cough suppressant dextromethorphan (DXM), the diet drug ephedrine, and caffeine In addition, other drugs similar to MDMA, such as MDA or PMA, are often sold as ecstasy, which can lead to overdose and death when the user takes additional doses to obtain the desired effect.

MDMA is a synthetic chemical made in labs. Seized MDMA in the U.S. is primarily manufactured in, and smuggled across our borders from, clandestine laboratories in Canada and, to a lesser extent, the Netherlands. A small number of MDMA clandestine laboratories have also been identified operating in the U.S.

MDMA is mainly distributed in tablet form. MDMA tablets are sold with logos, creating brand names for users to seek out. MDMA is also distributed in capsules, powder, and liquid forms.

MDMA use mainly involves swallowing tablets (50-150 mg), which are sometimes crushed and snorted, occasionally smoked but rarely injected. MDMA is also available as a powder. MDMA users usually take MDMA by "stacking" (taking three or more tablets at once) or by "piggy-backing" (taking a series of tablets over a short period of time). One trend among young adults is "candy flipping," which is the co-abuse of MDMA and LSD. MDMA is considered a "party drug." As with many other drugs of abuse, MDMA is rarely used alone. It is common for users to mix MDMA with other substances, such as alcohol and marijuana.

MDMA causes changes in perception, including euphoria and increased sensitivity to touch, energy, sensual and sexual arousal, need to be touched, and need for stimulation. All these effects usually occur within 30 to 45 minutes of swallowing the drug and usually last 4 to 6 hours, but they may occur or last weeks after ingestion. Clinical studies suggest that MDMA may increase the risk of long-term, perhaps permanent, problems with memory and learning. Studies suggest chronic use of MDMA can produce damage to the serotonin system. It is ironic that a drug that is taken to increase pleasure may cause damage that reduces a person's ability to feel pleasure.

Myths and Misunderstandings:

Does MDMA put holes in your brain?
MDMA does not put holes in your brain. This myth comes from messages broadcast by anti-drug campaigns in the late 1990s/early 2000s.

Is MDMA (ecstasy) powder purer than ecstasy pills?
Like most illegal drugs, the purity of MDMA changes all the time, so forms that might once have been more reliable cannot be guaranteed to remain so. It is quite easy for drug dealers to mix MDMA powder with any substance that looks like it, so taking MDMA powder does not necessarily mean you are not unknowingly taking other substances mixed with the drug.

Does MDMA (ecstasy) drain your spinal fluid?
No. This myth probably comes from experiments where researchers measured breakdown products of serotonin in the spinal fluid of animals who had taken MDMA. MDMA does not damage your spine.

Does MDMA (ecstasy) cause Parkinson's disease?
MDMA does not cause Parkinsons. This myth may come from an experiment where researchers accidentally gave methamphetamine (crystal meth) to laboratory monkeys instead of MDMA. There is a horribly toxic chemical with a four-letter acronym, MPTP, which does cause parkinsonism. It has appeared as an unwanted impurity in a heroin-like (opiate) drug called MPPP, causing the people who took the contaminated drug to 'freeze up' by destroying dopamine neurons in the brain, just as Parkinson's disease does. Neither MPTP or MPPP have any relation to MDMA.

Myths:

"Ecstasy will make me drink so much water that I'll die"
Although one of the most famous ecstasy-related deaths was caused by overhydration, MDMA itself will not make you drink yourself to death. The victim in this infamous case thought that by drinking a large amount of water, they would counteract an unpleasant ecstasy experience. Unfortunately, MDMA also makes it harder for the body to process water, meaning she died from water retention.

This doesn't mean you should avoid drinking water on ecstasy. Taking a very high dose of ecstasy can cause an inability to regulate your hydration, so you should make sure you're drinking water regularly. This is especially if you're dancing or exerting yourself.

"Ecstasy is a clubbing drug only"
Although MDMA is very popular for use in clubs due to its enhancement of music and dance, that doesn't mean it's exclusively a clubber's drug. Many people take it in a spiritual or therapeutic context. It can be used for various forms of personal and relationship development, and clinical trials are using it to treat sufferers of post-traumatic stress disorder.

"Ecstasy eats away at your brain"
There is no evidence that moderate use of MDMA (less than 100mg every few weeks) can cause damage to your brain.

Frequent, high dose use can cause heart problems and memory problems. Additionally, it's relatively easy to overdose on MDMA if it's combined with other drugs, especially PMA/PMMA. MDMA overdose can be lethal.

So although sensible use is relatively safe, it can be harmful in large amounts.

MDMA testing kits:
Because MDMA is so popular and because it goes well with dance parties, the demand for it usually exceeds supply - especially at any given location on any given night. This creates an opening for unscrupulous individuals to sell virtually anything as 'ecstasy'. While 'ecstasy' is the popular name for MDMA, the functional definition of ecstasy is any pill represented as MDMA on the street. Ecstasy pills are notoriously unreliable in content, more so than most other street drugs, and commonly contain either caffeine, ephedrine, amphetamines, MDA, MDE, DXM, or - in rare cases - DOB, and don't necessarily contain MDMA or any psychoactive. This problem has led to the development of simple MDMA testing kits that may help give the user a general sense of the content of a pill.

Molly vs Ecstasy vs MDMA:
MDMA is the official chemical name for the pure chemical compound - in an ideal world, Molly would be 100% pure MDMA. Molly is a street name for MDMA in powder form, often contained in clear capsules. "Molly" doesn't mean pure. Ecstasy is a street name for MDMA in pill/tablet form.

Caution:
Drugs sold as MDMA, Molly or Ecstasy are often impure. 87% of "Molly" analyzed by the DEA between 2009 and 2013 contained 0% MDMA, instead mostly containing "bath salts."

Safer and more enjoyable usage checklist:
I have no pre-existing health conditions that make MDMA less safe
I'm not taking medicines or supplements that may interact with MDMA
I have tested my MDMA with a reagent test
I have my supplements ready
I haven't rolled in at least the last ~5 weeks, ideally longer
I'm aware of the dosage guideline: your weight in kg + 50 = total dosage in mg for the night. I'm aware that a study found that positive effects are maximized between 81-100 mg.
I'll drink 250-500 ml/h (1-2 cups), definitely no more than 500 ml/h (2 cups), and ideally Gatorade instead of water
I'll stay cool to avoid heat stroke
I'll take MDMA in a safe, cool and positive environment
I'm aware that MDMA can bring to the surface issues that I may be emotionally struggling with
I know the signs of heat stroke and agree to pay attention to the friends I am rolling with
I know my intention for taking MDMA, even if it is just to have fun, and I will state it out loud to the people I plan to roll with

How to Manage MDMA Toxicity:

MDMA intoxication can cause severe life-threatening pathologies like hyperthermia, profound hyponatremia, and sympathomimetic toxicity. Human body cannot tolerate temperatures greater than 106 F for prolonged periods of time. Rapid temperature reduction with either ice bath immersion or cool water mist with fanning might be a possible solution.

Hyperthermia treatment is of the utmost importance. There are multiple ways to treat such elevated temperatures. If possible, immersion in an ice bath should be performed for rapid cooling. Benzodiazepines should be used to control psychomotor agitation and shivering. Cyproheptadine may be used for signs of serotonin syndrome. Ultimately the goal is to decrease the temperature as quickly as possible because the human body simply cannot survive such high temperature for long.

mdma effects -positivechoices.org

Ecstacy Deaths:

Ecstasy Deaths

MDMA and Sex
Many users will abuse ecstasy simply for the 'body high' - the senses of feeling and touch that become intensely pleasurable. This physical sensitivity, paired with the feelings of self-acceptance and empathy for others, can often lead to an increased sex drive and feelings of intimacy. This is why some people consider ecstasy to be an aphrodisiac, or even one of the date-rape drugs. Nevertheless, while MDMA may enhance sexual desire, it also impairs sexual performance. Males may be unable to achieve erection under the peak effects of ecstasy, while both sexes have great difficulty in achieving orgasm. In addition, due to the effects of dehydration and heat exhaustion, both sexes can encounter a lack of lubrication - the number one cause of condom breakage. And because ecstasy lowers inhibitions and can heighten arousal, it can easily lead to risky behavior in which the user would not generally participate.

Sextasy:
There have been reports of a new combination of drugs that has been hitting the streets and club scenes. Ecstasy (a drug with stimulant and hallucinogenic effects) and Viagra (a prescription drug for erectile dysfunction) are being used as one, a combination known as "sextasy" or "trail mix." Together they produce a synergistic effect where the effects of the two drugs are greater then the effect of each drug individually. By combining the two drugs users are attempting to defeat the impotence side effect of ecstasy in order to increase sexual performance and functioning.

The mixture of these two drugs can produce severe side effects. One of the most well-known and frequent is known as "priapism," a condition in which an erection can last for four hours, which can lead to permanent damage.

How to Use MDMA (Molly):

  1. Be sure that you have set aside enough time in a comfortable setting. You will need about 3-4 hours for a typical dose without a booster.
  2. Make sure you have your dose measured and ready. Start with 90mg if you aren't sure what level is best for you.
  3. Swallow the pill, powder, or measured crystals.
  4. Once you take the MDMA, you will have about 30-60 minutes before the effects begin. This is another chance to make sure you get setup with anything you will want to have handy.
  5. As the MDMA begins to kick in, you will start to feel a sense of peacefulness and openness. However, it's a very subtle feeling
  6. Once the MDMA is in effect, you'll notice that your thoughts and emotions feel different. You'll experience a significant decrease in anxiety and fear and an openness to ideas and emotions that you may have avoided in the past.
  7. As you experience this process, try to stay as open to your feelings and ideas as you can.
  8. If you are taking MDMA with another individual, think about the same things. You may be trying to work through problems together or heal old wounds.
  9. Don't forget to just relax into the experience. Even if you are using MDMA to solve specific psychological, emotional, or relationship challenges, it's worth taking a few minutes just to relax and be present with the experience without any particular goals.
  10. If you want to prolong the peak of the experience - you can take a booster dose of about 60mg (or half the original dose) two hours after you first take the initial dose. This will add another 1.5 - 2 hours to the experience and will give you more time to work.
  11. As the effects of MDMA start to fade, you will likely still feel much of the same openness and relief from fear and anxiety. Gradually, you will start to feel back to your normal self, and this can lead to a bit of disappointment as old mental habits start to pop up. Getting to such a free space and then coming back to yourself can leave you longing to always be so free. But as you think about your experience and the ideas and feelings you had, you'll realize that so much of that freedom and openness is still with you. Take some time to think about what's happened and to remind yourself to bring some of that openness into your day to day life.
  12. Once the MDMA has worn off, be sure that you drink lots of water and get a long peaceful sleep at night. MDMA can be mentally tiring and you need to rejuvenate

How Long Does Ecstasy Last?
The duration of effects varies depending on how a person uses the drug. Unlike other stimulants, ecstasy is most often swallowed, according to the Drug Enforcement Administration. When people swallow the drug, they usually feel the effects within 30 to 45 minutes. These primary effects tend to persist for between four and six hours. Some minor effects can be felt for up to two days. MDMA can stay in your system for more than 40 hours, and most drug tests can detect MDMA in the urine two to four days after last use. Repeatedly using the drug can increase the amount of time it takes for the body to metabolize it, increasing the potency and duration of the effects.

MDMA
Duration:

The world's most popular empathogen with powerful pro-social effects. Has been strongly linked to cognitive decline in excess. Popular at parties, it is often sold in powder or in pills, and may be adulterated with other similar chemicals.

NOTE: Higher doses increase neurotoxic effects

RouteOnsetDurationAfter Effects
Tripsit Factsheets
All ROAs:20-70 minutes3-5 hours1-72 hours
MDMA Duration
Detection:
1-3 days single use, 3-5 days heavy use
Marquis:
Black (may have purple tint)
General-advice:
Only roll every 2-3 months.

How often can I take it?

The Three Month Rule:
MDMA works by causing large amounts of serotonin to be released, along with other neurotransmitters like dopamine. After using MDMA, your serotonin levels are lowered, and it takes a long time for your brain to build more serotonin. If you take ecstasy on a regular basis, you may be releasing and depleting your serotonin before it has a chance to fully replenish itself. This means you will be operating on lower-than-normal serotonin levels most of the time, and this can lead to depression or worsen depressive symptoms. It is recommended that you leave at the very least 1 - 2 months between uses, ideally 3. Save MDMA for special occasions or events only, and use it very sparingly.

Will MDMA Show Up On a Drug Test?
Depends on the time, depends on the test and depends on your trickery. MDMA is usually detectable in body fluids - blood, saliva and urine - for up to five days. However, like most drugs, it can also show up in a hair test for several months. Whether that'll show up on a drug test? You can't really say, generally, because there are so many different kinds. Drug tests aren't good at proving when you took a substance.

Is MDMA Addictive?
MDMA is not physically addictive. However, the drug can often take on great importance in people's lives, and some people become compulsive, every-weekend users. Compulsive users may be unconsciously trying to self-medicate for depression. However, MDMA is not a good long-term antidepressant. Effective treatments for depression are available from a qualified physician. If taken too frequently, MDMA can stop working. Users report that the "magic" goes away. This can last for many years. Remember, less is more.

Ecstasy/MDMA Addiction and Abuse:
People who take the drug experience an increase in energy and heightened emotional sensitivity, and the neurotransmitter serotonin is released in the brain, which causes a short-term, elevated mood. The drug can also serve as an antidepressant for a very short amount of time. This is a main reason that people become dependent on ecstasy/MDMA and begin misusing the drug. When people experience the feelings of happiness and heightened emotional sensitivity, they associate the drug psychologically to positive experiences. As people take the drug more often, a physical dependence forms. The brain relies on MDMA's presence to know when to release serotonin. When the drug is not present, the brain might not release this important chemical and people may experience long stretches of depression or negative thoughts. As people continue to take ecstasy, this connection to happiness becomes stronger and more difficult to break.

Prior to 2005 most tablets tested in Europe contained MDMA or another MDMA-like substance (MDEA, MDA) as the only psychoactive ingredient. Changes occurring in the late 2000s saw the virtual disappearance of MDMA as the active ingredient in ecstasy tablets, accompanied by increased tablet adulteration/substitution with other psychoactive substances. The downward trend was most pronounced in 2009 when seizure data suggest that the majority of MDMA tablets on European markets contained no MDMA at all.

From 2010/11 MDMA products have gradually re-emerged on the market, often at higher levels of purity. The first powders that appeared after the MDMA shortage were reportedly very pure; however, their quality declined over time. The subsequent market development saw the growing popularity of MDMA crystals, which were less easy to adulterate. Some recently produced batches of MDMA tablets contained discernible crystals, apparently as a strategy to increase user trust.

In the 1990s and 2000s the average MDMA content of tablets was somewhere between 50 - 80 mg. At present the averages are closer to 125 mg MDMA per tablet, while there are also 'super pills' found on the market in some countries with a reported range of 270 - 340 mg. There are reports of large variations in the dosage in similar looking tablets.

Ecstasy Getting Stronger

Netherlands, which tests around 10 000 drug samples annually, confirm both the re-emergence of MDMA in the country, starting in 2011 - 12 then increasing rapidly from 2013, and the trend of increasing purity of MDMA pills. Over half (53 %) of all ecstasy tablets tested in 2015 contained over 140 mg of MDMA compared to just 3 % in 2009.

In addition to increases in MDMA content, there has also been an increase in the size of some of the tablets available. In France the SINTES monitoring system reported that the weight of MDMA pills increased on average from 204 mg in 2009 to 325 mg in 2014.

EMCDDA PDF MDMA

MDMA is a synthetic substance:
Although proposed as an aid to psychiatric counselling, therapeutic use is extremely limited. Illicit MDMA is normally seen as tablets, many of which are manufactured in Europe. It acts as a central nervous system (CNS) stimulant and has a weak hallucinogenic property more accurately described as increased sensory awareness. MDMA is under international control.

Illicit Ecstasy Sources:
Although some clandestine labs have been discovered operating inside the United States, most of the MDMA sold in the U.S. is manufactured in Canada and smuggled into the U.S. A small percentage of Ecstasy in the U.S. is manufactured in the Netherlands.

How much do you know about the synthetic "party" drugs MDMA and ecstasy?

Question 3 out of 8:

Why do users of MDMA sometimes need to use a pacifier?

To look cool
To keep them from grinding their teeth.
To keep their tongues active

Correct:
Users of ecstasy or MDMA (also known as Molly) use pacifiers to keep them from grinding their teeth down when they are high.

Is it safe to use MDMA while I breastfeed?
Studies have found MDMA in the breast milk of mothers who used this drug. Amphetamine drugs (like MDMA) are concentrated in the breast milk, meaning they are found at higher levels in breastmilk than in the mother's blood. The effect of MDMA on a breastfeeding infant is not known. However, the use of MDMA in breastfeeding is strongly discouraged. If MDMA has already been taken, it has been recommended to not breastfeed for 48 hours. During this time breast milk should be expressed and discarded. Be sure to discuss your breastfeeding questions with your healthcare provider

Mothertobaby PDF MDMA

MDMA (Ecstasy) falls into two drug categories:
MDMA is an amphetamine derivative. However, the synthesis process alters the original amphetamine molecule so significantly that it loses a part of its stimulant effect and gains hallucinogenic properties. It is for this reason that MDMA falls into 2 categories of drugs: stimulants and hallucinogens.

Phase 3 Trials: MDMA for PTSD a Breakthrough Therapy:
MAPS' highest priority project is sponsoring Food and Drug Administration (FDA) drug development research into 3,4-methylenedioxymethamphetamine (MDMA) assisted psychotherapy for the treatment of post traumatic stress disorder (PTSD). FDA has designated MDMA assisted psychotherapy for PTSD a Breakthrough Therapy, and has come to agreement with MAPS on Phase 3 protocol designs after a rigorous Special Protocol Assessment (SPA) process. MAPS' goal is to develop MDMA-assisted psychotherapy for PTSD into an FDA approved prescription treatment by the end of 2021.

We are studying whether MDMA assisted psychotherapy can help heal the psychological and emotional damage caused by sexual assault, war, violent crime, and other traumas. We also sponsored completed studies of MDMA assisted psychotherapy for autistic adults with social anxiety, and MDMA assisted psychotherapy for anxiety related to life threatening illnesses.

DEA PDF MDMA Chem Info

SWGDRUG PDF MDMA

Caymanchem PDF MDMA

"Molly", short for 'molecule', was recognized as a slang term for crystalline or powder MDMA in the 2000s

  
Prescribing MDMA and psilocybin: who will get the drugs and how will they help? - Explainer: doctors say the drugs can help patients work through psychotherapy for PTSD – a condition that will affect one in five people in their lifetimes
Monday February 06, 2023 - theguardian.com

MDMA News: Optimi's New Drug Now Available, Revive Advances Transdermal Patch Evaluations - Considering MDMA will likely be the first psychedelic to receive FDA approval for psychotherapeutic use to treat serious mental health conditions such as PTSD, several publicly listed companies are developing related products such as next-generation psychedelics- or a new delivery system to the human body.
Monday February 06, 2023 - msn.com

Optimi Health Completes First Production of Novel MDMA Drug Candidate OPTI-MHCL - Optimi Health Completes First Production of Novel MDMA Drug Candidate OPTI-MHCL Full end-to-end, GMP manufacturing of OPTI-MHCL solidifies the Company’s plan to address the global demand for MDMA in 2023 and beyond
Sunday February 05, 2023 - asiaone.com

Wastewater testing reveals drop in meth and MDMA use, cocaine on the rise - Northland is the district with the highest level of meth consumption, and Auckland is the city with the biggest cocaine problem.
Monday February 06, 2023 - stuff.co.nz

  
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