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Created Apr 2019 | Updated Nov 2020


  • [CRACK]
  • [COKE]
  • [BLOW]
  • [SNOW]

DEA CODE 9041: Schedule 2 Narcotic



Cocaine is an alkaloid ester extracted from the leaves of plants including coca. Cocaine is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Cocaine is addictive due to its effect on the reward pathway in the brain. After a short period of use, there is a high risk that dependence will occur. Its use also increases the risk of stroke, myocardial infarction, lung problems in those who smoke it, blood infections, and sudden cardiac death.

Cocaine sold on the street is commonly mixed with local anesthetics, cornstarch, quinine, or sugar which can result in additional toxicity. Following repeated doses, a person may have decreased the ability to feel pleasure and be very physically tired. Cocaine acts by inhibiting the reuptake of serotonin, norepinephrine, and dopamine. This results in greater concentrations of these three neurotransmitters in the brain. It can easily cross the blood-brain barrier and may lead to the breakdown of the barrier.

Powdered cocaine (cocaine hydrochloride) is a stimulant that is extracted from the leaves of the coca plant, which is native to South America. In the late 19th century cocaine was used as an anesthetic, but the availability of safer drugs rendered many of its medical applications obsolete. Today powdered cocaine is abused for the intense euphoric effects it produces.

NDIC PDF Cocaine

What is cocaine?
On the street it is usually sold as a fine, white powder. The powdered, hydrochloride salt form can be snorted or dissolved in water and injected. Use in any form is illegal in the U.S. when used as recreational drug.

Freebase is cocaine hydrochloride that is processed with ammonia and heated to remove the hydrochloride salt. This 'freebase' form is not water-soluble; the powder can be heated and its vapors smoked due to the lower melting point. Diethyl ether is used to process freebase and is highly flammable and volatile, often leading to lab explosions and bodily injury such as burns. It produces a much more intense "rush" than snorting the drug and can be extremely addictive due to the quick high and repeated use. People who use this drug in any form may binge to maintain their high.

Crack cocaine is another form that is processed into a rock form using baking soda and may contain a high percentage of impurities.

The term "crack" refers to the crackling sound heard when it is heated prior to smoking.

Crack abuse in the U.S. rose in the mid-1980's and is considered the most addictive form of the drug.

Most often the powder is snorted, and the drug is laid out on a mirror, plate or other flat surface, separated into 'lines' and snorted nasally through a straw, rolled-up dollar bill or other inhaling device. The cocaine is absorbed into the bloodstream through the nasal tissues. The effect, or 'high' with snorting may last 15 to 30 minutes, but does not occur as quickly as smoking or injecting it. Alternatively, smoking crack or injecting cocaine may have a rapid and more intense effect, but the 'high' only lasts 5 to 10 minutes, often with an intense "crash", which leads to repeated use to sustain the high, an action called 'binging'.

How is cocaine used medically?
Cocaine is available in the U.S. as a prescription solution for local mucosal anesthesia, and for some eye, ear, and throat surgeries, but is infrequently used because of safer alternatives, such as lidocaine or benzocaine. A nasal solution is used for the induction of local anesthesia of the mucous membranes when performing diagnostic procedures and surgeries on or through the nasal cavities in adults. Topical cocaine may be administered by using cotton applicators or packs, installed into a cavity, or as a spray.

Brands names for FDA-approved topical cocaine solution products include Goprelto and Numbrino.

Cocaine is a powerfully addictive stimulant drug made from the leaves of the coca plant native to South America.

  • Street dealers often mix it with things like cornstarch, talcum powder, or flour to increase profits.
  • They may also mix it with other drugs such as the stimulant amphetamine or the synthetic opioid fentanyl.
  • People snort cocaine powder through the nose, or rub it into their gums. Others dissolve the powder and inject it into the bloodstream, or inject a combination of cocaine and heroin, called a Speedball. Another popular method of use is to smoke Crack cocaine.
  • Cocaine increases levels of the natural chemical messenger dopamine in brain circuits related to the control of movement and reward.
  • A person can overdose on cocaine, which can lead to death.
  • Behavioral therapy may be used to treat cocaine addiction.
  • While no government-approved medicines are currently available to treat cocaine addiction, researchers are testing some treatments that have been used to treat other disorders.

US Cocaine Drug Testing Psoitivity

Cocaine is usually distributed as a white, crystalline powder. Cocaine is often diluted ("cut") with a variety of substances, the most common of which are sugars and local anesthetics. It is "cut" to stretch the amount of the product and increase profits for dealers. In contrast, cocaine base (crack) looks like small, irregularly shaped chunks (or "rocks") of a whitish solid. Powdered cocaine can be snorted or injected into the veins after dissolving in water. Cocaine base (crack) is smoked, either alone or on marijuana or tobacco. Cocaine is also used in combination with an opiate, like heroin, a practice known as "speedballing." Although injecting into veins or muscles, snorting, and smoking are the common ways of using cocaine, all mucous membranes readily absorb cocaine. Cocaine users typically binge on the drug until they are exhausted or run out of cocaine.

Following smoking or intravenous injection, cocaine reaches the brain in seconds, with a rapid buildup in levels. This results in a rapid-onset, intense euphoric effect known as a "rush." By contrast, the euphoria caused by snorting cocaine is less intense and does not happen as quickly due to the slower build-up of the drug in the brain. Other effects include increased alertness and excitation, as well as restlessness, irritability, and anxiety. Tolerance to cocaine's effects develops rapidly, causing users to take higher and higher doses. Taking high doses of cocaine or prolonged use, such as binging, usually causes paranoia. The crash that follows euphoria is characterized by mental and physical exhaustion, sleep, and depression lasting several days. Following the crash, users experience a craving to use cocaine again.

Chronic snorting of cocaine leads to the erosion of the upper nasal cavity.

History of Cocaine:
Early Spanish explorers noticed how the native people of South America were able to fight off fatigue by chewing on coca leaves. A medical account of the coca plant was published in 1569. In 1860, Albert Neiman isolated cocaine from the coca leaf and described the anesthetic action of the drug when it was put on his tongue. Angelo Mariani, in the early 1880s produced a "medicinal" wine, called Vin Mariani, that contained 11% alcohol and 6.5 mg of cocaine in every ounce. The famous psychotherapist, Sigmund Freud, in 1884, recommended cocaine for a variety of illnesses and for alcohol and morphine addictions. Unfortunately, many of his patients went on to become addicted to cocaine! In 1886, John Pemberton developed Coca Cola, a drink that contained cocaine and caffeine. Cocaine was REMOVED from Coca Cola in 1906 (but it still has the caffeine). The Harrison Narcotic Act in 1914 made cocaine illegal. Finally, in 1985, crack cocaine was introduced and rapidly became a major drug problem.

Cocaine is one of the most dangerous drugs known to man. Once a person begins taking the drug, it has proven almost impossible to become free of its grip physically and mentally. Physically it stimulates key receptors (nerve endings that sense changes in the body) within the brain that, in turn, create a euphoria to which users quickly develop a tolerance. Only higher dosages and more frequent use can bring about the same effect. It is most often sniffed, with the powder absorbed into the bloodstream through the nasal tissues. It can also be ingested or rubbed into the gums. To more rapidly absorb the drug into the body, abusers inject it, but this substantially increases the risk of overdose. Inhaling it as smoke or vapor speeds absorption with less health risk than injection.

Today, cocaine is a worldwide, multi-billion dollar enterprise. Users encompass all ages, occupations and economic levels, even schoolchildren as young as eight years old.

Cocaine use can lead to death from respiratory (breathing) failure, stroke, cerebral hemorrhage (bleeding in the brain) or heart attack. Children of cocaine addicted mothers come into the world as addicts themselves. Many suffer birth defects and many other problems.

Despite its dangers, cocaine use continues to increase - likely because users find it so difficult to escape from the first steps taken down the long dark road that leads to addiction.

  • Cocaine is a short-acting stimulant and takes effect by increasing the amount of neurotransmitters (brain chemicals) such as dopamine, serotonin and norepinephrine. Cocaine is produced from the leaves of the coca plant, which is native to South America.
  • When snorted or injected, cocaine quickly produces an intense 'rush', with the purity and the amount of the drug taken determining its intensity. The rush doesn't last very long usually only 30-45 minutes, if snorted.
  • Cocaine is a very unpredictable drug. Toxic (and sometimes fatal) reactions can occur regardless of the amount used, whether the person is a first-time, occasional or regular user. Mixing drugs causes additional problems.
  • The most serious physical consequence of cocaine use concerns the heart and the risk of stroke. Cocaine may cause heart attacks by a combination of increasing oxygen demand, constriction of the coronary arteries and enlargement of the heart.
  • One major harm associated with regular cocaine use is the development of a cocaine-induced paranoid psychosis.
  • There is no proven drug treatment for cocaine dependence.


Cocaine Factsheet:

Cocaine Factsheet

"Cocaine" comprises at least two distinct drug products: powder cocaine on the one hand, and a range of cocaine base products, mostly falling under the heading of "crack", on the other. Powder cocaine is a milder drug generally snorted by the wealthy, while crack and other base products present an intense high favoured by the poorer users. Chemically, the substance consumed is the same, but the addition of baking soda and heat allows cocaine to be smoked, a far more direct method of ingestion. Both products are derived from a plant cultivated on some 170,000 hectares in remote areas of Colombia, Peru and the Plurinational State of Bolivia. From there, cocaine is distributed to at least 174 countries around the world.

USA Cocaine Consumption


High doses of cocaine can be associated with toxic reactions including hyperthermia, rhabdomyolysis, shock and acute liver injury which can be severe and even fatal.

Cocaine Hepatotoxicity:
Cocaine has many serious medical consequences including cardiac arrhythmias, coronary artery spasm and myocardial infarction, cerebrovascular accidents, subarachnoid hemorrhage, seizures, hallucinations, intestinal ischemia, renal infarction, rhabdomyolysis and acute liver injury. Cocaine is a not infrequent cause of sudden "unexplained" death in young adults. Hepatotoxicity usually arises hours to a few days after an acute overdose, generally following or accompanying other major organ involvement. The clinical phenotype of cocaine hepatototoxicity is usually acute hepatic necrosis. Initially, serum aminotransferase and LDH levels are markedly elevated with minimal increase in alkaline phosphatase. The prothrombin time becomes abnormal rapidly and may also reflect disseminated intravascular coagulation (DIC). The serum bilirubin begins to rise after 2 to 3 days. Immunoallergic features and autoantibodies are usually absent. Liver histology usually shows centrolobular (zone 3) necrosis and fatty change, features that resemble ischemic hepatitis or liver injury due to hyperthermia, factors that may partially mediate the hepatotoxic effects of cocaine. In self-limited cases, recovery is rapid and serum aminotransferase levels usually return to normal within 1 to 2 weeks.

A [HD] Likelihood score: A[HD] (well known cause of acute liver injury, but only when taken as an overdose).


Summary of Use During Lactation:
No data are available on the medical use of cocaine in nursing mothers. However, because of its chemical nature, high concentrations of cocaine are expected in milk.

Cocaine and its metabolites are detectable in breastmilk, although data are from random breastmilk screening of mothers who used cocaine recreationally rather than controlled studies.

Cocaine breastmilk concentrations have varied over 100-fold in these reports.

Newborn infants are extremely sensitive to cocaine because they have not yet developed the enzyme that inactivates it and serious adverse reactions have been reported in a newborn infant exposed to cocaine via breastmilk.

Cocaine should not be used by nursing mothers or smoked (such as with "crack") by anyone in the vicinity of infants because the infants can be exposed by inhaling the smoke.

Other factors to consider are the possibility of positive urine tests in breastfed infants which might have legal implications, and the possibility of other harmful contaminants in street drugs. A breastfeeding abstinence period of 24 hours has been suggested for women who occasionally use cocaine while breastfeeding, based on the rapid elimination of cocaine by the mother. Some authors have proposed that breastfeeding be discontinued only for those infants who test positive for cocaine exposure. However, the Academy of Breastfeeding Medicine suggests that women who have abused cocaine generally should not breastfeed unless they have a negative maternal urine toxicology at delivery, have been abstinent for at least 90 days, are in a substance abuse treatment program and plan to continue it in the postpartum period, have the approval of their substance abuse counselor, have been engaged and compliant in their prenatal care, and have no other contraindications to breastfeeding.

Drug Levels:
Propoxyphene is metabolized to active norpropoxyphene (25%) and to several inactive metabolites.

Norpropoxyphene has a 30 to 36 hour half-life.

The oral bioavailability of norpropoxyphene is unknown. Propoxyphene is available in 2 salt forms: 65 mg of the hydrochloride form is equivalent to 100 mg of the napsylate.

Effects on Lactation and Breastmilk:
Long-term cocaine use can result in chronic, low-level hyperprolactinemia.

The prolactin level in a mother with established lactation may not affect her ability to breastfeed.

Mothers who use cocaine initiate breastfeeding of their infants less frequently than mothers who do not use cocaine.


A highly popular, short acting CNS stimulant that works by blocking the reuptake of dopamine, serotonin, and norepinephrine. It is known to increase euphoria, confidence, sex-drive, focus, body temperature, and heart rate. Cocaine can cause severe vasoconstriction and is known to be cardiotoxic and have a high potential for compulsive redosing and addiction.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
All ROAs:Rapid.1-1.5 hours1-4 hours
Cocaine Duration
  • Saliva: 1 day
  • Urine: 4-5 days
  • Hair: up to 90 days
Clear (No change)
  • coke
Elevated mood. Increase in irritability, hyper-inflated ego, euphoria, stimulation, raised heartrate, numbing effects depending on ROA, nausea (particularly at high doses)

ndic PDF Cocaine Fast Facts

PMC PDF Cocaine


EMCDDA PDF Cocaine Market

My dealer told me my coke is pure. Is it? No. If you are in any country outside of South America, there is a 100% chance your cocaine is not going to be pure.

Cocaine speeds up your whole body. You may feel full of energy, happy, and excited. But then your mood can change. You can become angry, nervous, and afraid that someone's out to get you. You might do things that make no sense. After the "high" of the cocaine wears off, you can "crash" and feel tired and sad for days. You also get a strong craving to take the drug again to try to feel better. No matter how cocaine is taken, it is dangerous. Some of the most common serious problems include heart attack and stroke. You are also at risk for HIV/AIDS and hepatitis, from sharing needles or having unsafe sex. Cocaine is more dangerous when combined with other drugs or alcohol. It is easy to lose control over cocaine use and become addicted. Then, even if you get treatment, it can be hard to stay off the drug. People who stopped using cocaine can still feel strong cravings for the drug, sometimes even years later.


Cocaine is the second most frequently used illegal drug globally, after cannabis. Use is highest in North America followed by Europe and South America.

  • A strong stimulant
  • Most frequently used as a recreational drug
  • It is commonly snorted, inhaled as smoke, or dissolved and injected into a vein.
  • Mental effects may include an intense feeling of happiness, sexual arousal, loss of contact with reality, or agitation.
  • Physical symptoms may include a fast heart rate, sweating, and large pupils.
  • High doses can result in very high blood pressure or body temperature.
  • Effects begin within seconds to minutes of use and last between five and ninety minutes.
  • Cocaine is addictive due to its effect on the reward pathway in the brain. After a short period of use, there is a high risk that dependence will occur.
With further processing, crack cocaine can be produced from cocaine.

Cocaine was first isolated from the leaves in 1860

Cocaine has a small number of accepted medical uses, such as numbing and decreasing bleeding during nasal surgery.

Cocaine sold on the street is commonly mixed with local anesthetics, cornstarch, quinine, or sugar, which can result in additional toxicity.

Cocaine infused rollerblades from Colombia lead to Kenosha drug bust - CHICAGO (CBS) -- A package containing rollerblades with wheels infused with cocaine has led to a drug bust at a home in Kenosha, Wisconsin, officials say.
Saturday March 02, 2024 -

Kenosha authorities discover cocaine infused in rollerblade wheels in package from Colombia - The wheels were infused with a gelatin-like substance which contained a trace of the illegal drug, the Kenosha County Sheriff's Department said. The discovery led authorities to discovering over 1,000 ...
Saturday March 02, 2024 -

Cocaine gang's courier was part of plot to throw drugs into Welsh prison - Their operation was said to have been already "well established" by this time, being involved in the acquisition and adulteration of kilo quantities of cocaine before selling them on for profit.
Saturday March 02, 2024 -

Former Honduran president Juan Orlando Hernández charged with running cocaine - As he listened to the lurid testimony against him in a New York courtroom this week, Juan Orlando Hernández may have wondered how he became so luckless as to be charged by the US Department of Justice ...
Sunday March 03, 2024 -

Matt Riddle admits he failed multiple WWE drug tests for cocaine before his departure - Matt Riddle told Ariel Helwani on "The MMA Hour" cocaine was reason each time he failed a drug test while in WWE.
Thursday February 29, 2024 -

Former WWE star admits to failing multiple drug tests due to cocaine use - Former WWE star Matt Riddle revealed he failed multiple drug tests toward the end of his time with the organization after using cocaine.
Thursday February 29, 2024 -

'Dying before our eyes': Overdose deaths push Oregon lawmakers to end drug decriminalization 'experiment' - Oregon State Sen. Tim Knopp, a Republican, said the disastrous consequences of drug decriminalization in the Beaver State compelled lawmakers to walk back the policy.
Saturday March 02, 2024 -

Deaths from cocaine increase in CT as other drug overdoses fall: medical examiner - But despite the positive trend downward, drug deaths involving cocaine increased from 684 in 2022 to 724 deaths in 2023. “The cocaine increase may be related to the combined use of fentanyl and ...
Friday March 01, 2024 -

Drug dealer buried crack cocaine in back garden - A man who buried crack cocaine in a back garden has been jailed for three years and four months.Merseyside Police said officers found 1.1lb (500g) of the drug worth £44,000 at a house on Akenside ...
Tuesday February 27, 2024 -

Matt Riddle failed WWE drug tests after doing cocaine at strip clubs - Matt Riddle finally opened up about the circumstances around his WWE release, including failed drug tests stemming from cocaine use at strip clubs. The former United States and Raw tag team champion, ...
Wednesday February 28, 2024 -

U.K. police find $568 million of cocaine hidden in bananas, shattering drug-seizure record - British authorities on Friday said they had found more than 12,500 pounds of cocaine hidden in a shipment of bananas, shattering the record for the biggest single seizure of hard drugs in the country.
Thursday February 22, 2024 -

NDLEA arrests Vietnam-bound businessman with cocaine at Abuja airport - Babafemi said the drugs were concealed in the suspect’s luggage while he ... swooped on members of a syndicate that deals in methamphetamine, cocaine and heroin in their hideouts in parts of Lagos.
Saturday March 02, 2024 -

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