4-MEC:
http://www.wnfo.org.uk/drugs/4-mec/

4-MEC

Duration: A substituted cathinone stimulant; little is known about its safety or subjective effects. It is believed to have similar effects to mephedrone, but with a lower potency and a stronger stimulating character.
Route	Onset	Duration	After Effects
Tripsit Factsheets
4-MEC Basic Information: http://drugs.tripsit.me/4-MEC
Oral:	15-45 minutes	2-5 hours	2-4 hours
Effects: Euphoria, increased energy/alertness, decreased need for sleep, increased sociability, mood lift, increased sexuality, excessive talking, decreased appetite, weight loss, sweating, disturbed sleep patterns, bruxism, visual and auditory hallucinations, itchiness, aggressiveness, moodiness.

World Health Organization 2016:
4-Methylethcathinone (2-(ethylamino)-1-(4-methylphenyl)propan-1-one), also known as 4-MEC, has emerged in recent years as a recreational psychostimulant. Its homolog mephedrone (4-methylmethcathinone) is listed as a Schedule II substance under the 1971 United Nations Convention on Psychotropic Substances.The first official notification submitted to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) by a European member state was 2010. Since then it has been detected across the globe and marketed as a "research chemical" although it has also been detected as a constituent in branded products available for purchase viathe Internet or brick-and-mortar shops.

4-MEC is a psychostimulant with monoamine transporter activity with indications of abuse liability. Some data obtained from the analysis of user reports suggest that 4-MEC produces euphoria, a sense of well being,psychostimulant effects and lack of comedown symptomatology and that these appear to be less intense and short-lived compared to mephedrone. Conflicting information is available related to the urge of redosing, craving and bingeing. Negative effects associated with 4-MEC use include excessive sweating in the armpits, nausea, and vomiting but also jaw clenching, nystagmus, heart palpitations, loss of sightand migraine.

The available data so far also suggest that it may also function as a serotonin releasing agent but not dopamine, which would differentiate it from its homolog mephedrone.

Further studies are needed to assess the dependence potential.The number of case reports that demonstrate a causal relationship between 4-MEC consumption and fatal intoxication is relatively limited.There is no known therapeutic and medical use.

4-Methylethcathinone (4-MEC)Critical Review Report (PDF 38 pages):
https://www.who.int/medicines/access/controlled-substances/4.3_4-MEC_CritReview.pdf?ua=1

4-MEC Summary Sheet:
https://psychonautwiki.org/wiki/Talk:4-MEC

4-Methylethcathinone Experience Reports:
https://www.erowid.org/experiences/subs/exp_4Methylethcathinone.shtml

4-methylethcathinone Monograph (PDF 5 pages):
http://www.swgdrug.org/Monographs/4-MEC.pdf

4-Methylethcathinone (hydrochloride) Safety Data Sheet (PDF 5 pages):
https://www.caymanchem.com/msdss/9001069m.pdf

Methandriol:
https://drugs.ncats.io/drug/8XIW70Q5I3

Methylandrostenediol (methandriol for short) is an anabolic steroid derived from dihydrotestosterone. The drug itself is manufactured in two very distinct forms. The first is unesterified (straight) methylandrostenediol, which is used when making an oral medication with this steroid (although an injectable once existed in the U.S.). It is also found as esterified methylandrostenediol dipropionate, which is prepared as an injectable. The added propionate esters in the injectable form extend the activity of the drug for several days. Basically, methandriol drugs are altered c17-alkylated forms of 5-androstenediol. Methandriol is classified as a weak anabolic with weak androgenic properties. It also seems to display some level of estrogenic activity, making this steroid less ideal for dieting. The drug is generally considered too mild, and is not widely popular among bodybuilders and athletes. Sometimes, however, it is used in place of other anabolic/androgenic agents in bulking stacks when available.

Steroid Profiles - Methandriol and Methandriol Dipropionate:
https://anabolic.org/methandriol-dipropionate/

One of the more rare and exotic anabolic steroids:
Methandriol (or MAD as I like to call it) seems to be one of the more rare and exotic anabolic steroids. It is actually 5-androstenediol (5AD) that has had its chemical structure modified by adding a methyl group so the compound can resist being broken-down by the liver when taken orally. This results in better utilization by the body and is called 17-alpha alkylation (17AA). The first aspect that will be addressed is the one that most interests bodybuilders, the muscle building potential of the drug. With an anabolic (muscle building) effect of 20-60 (compared testosterone which has an anabolic rating of 100), not much muscle gain can be expected from MAD use. It is also slightly androgenic, again when compared to testosterone which has an androgenic effect of 100 MAD only rates 30-60. Methandriol low androgenic properties may be a blessing and a curse, on one hand with its low androgenic effects the drug can be used without worries by prone individuals who suffer from prostate problems, hair loss and acne. It may also be used by female bodybuilders who wish to avoid the masculinizing side effects of androgens once they stick to a reasonable dosage and cycle duration. On the other hand the benefits of using an androgenic steroid are lost, there is a direct correlation between a drugs androgenic levels and strength gains, highly androgenic steroids also tend to aid in fat loss by binding strongly to the androgen receptor (A.R). So not much muscle or strength gain from this one. So what the hell is it good for? Glad you asked. Methandriol has been shown to have an affinity for glucocorticoid-binding sites so this may result in an anti-catabolic (muscle destroying) effect by inhibiting the muscle wasting effects of glucocorticoid hormones also the parent hormone of methandriol, 5-androstenediol (5AD) has been shown to promote favorable immune function.

Steroid Profiles - Methandriol:
https://www.steroid.com/Methandriol.php

Magnifies the effects of other steroids:
The best results can be obtained, however, if Methandriol Dipropionate is not taken alone but in combination with another steroid. This is because Methandriol Dipropionate is able to magnify the effects of other steroid compounds. It does this by increasingly sensitizing the androgenic receptors of the muscle cell, allowing a higher amount of the steroid molecules of the additionally taken steroids to be absorbed by the receptors. This also explains why injectable Methandriol Dipropionate is only available today as a combination compound with an additional steroid substance. Injectable Methandriol Dipropionate is only available in the Australian veterinary steroids Drive, Spectriol, Geldabol, and Filibol Forte so that procurement of the compound is difficult. The few athletes using this drug report good strength gains, a solid muscle gain, and low water retention. The combination steroids aromatize only slightly so, when taking only Methandriol Dipropionate, the use of antiestrogens is perhaps appropriate. The injectable form is only slightly toxic.

Steroid Hormone Powder Methandriol Dipropionate:
https://www.worldofchemicals.com/chemicals/chemical-suppliers/99-purity-high-quality-steroid-hormone-powder-methandriol-dipropionate-3593-85-9.html

Tissue Repair:
Methandriol comes as an injectable form and oral pills, all of which are highly bio-available. Its powerful tissue-formulation properties and amazing muscle-building properties make it a popular option in the sporting world. It has been supported by the fact that it can stimulate hormones responsible for tissue repair without having any adverse effects such as virilization. It is the reason it has been used for many years as a tissue-builder.

A Robust Description Of Methandriol:
https://anabolicsteroiddrugs.com/methandriol/

Methylandrostenediol History:
Methylandrostenediol was first described in 1935, making this a very old agent as far as synthetic anabolic steroids are concerned. Methylandrostendiol was developed into a medicine by Organon, which sold it in the United States under the Stenediol brand name in both oral (methylandrostenediol) and injectable (methylandrostendiol dipropionate) forms. Many other generics and other brands of methylandrostenediol soon followed, and the drug was a popular anabolic agent in the United States during the 1950's. Methylandrostenediol was essentially the first steroid perceived to have a notable separation of anabolic (higher) and androgenic (lower) effect, a persistent goal of pharmaceutical developers. Early product literature described it as, "a steroid which has considerable of the male hormone's tissuebuilding action without to the same extent causing virilization." It was indicated for use as a, "tissue-builder in cases of retarded growth or failure to gain weight accompanied by protein wastage, negative nitrogen balance, or failure to build body proteins." Early assessments of methylandrostenediol being primarily anabolic in nature did not hold up well with later extensive use in humans. It was eventually determined that in doses sufficient to promote weight gain, its anabolic properties were accompanied by significant androgenic activity. Ultimately, this drug would be viewed as one of balanced anabolic and androgenic action, not as a highly anabolic agent as originally thought. Organon would go on to develop more effective anabolic agents, such as their 19-nor series of drugs including Durabolin, Deca-Durabolin, and Maxibolin, and eventually discontinued the Stenediol Methandriol products. The other U.S. brand and generic forms of the drug would follow as well, although methylandrostenediol would persist in the U.S. scene for some time. Currently, no domestic source of the drug exists, although it is still found in certain international markets. It seems most prominent in Australia at the present time, where it remains included in a number of veterinary anabolic steroid products.

Methylandrostenediol Side Effects:

• Estrogenic
• Androgenic
• Hepatotoxicity
• Cardiovascular
• Testosterone Suppression

This drug is derived from androstenediol, which is a metabolite of testosterone. It has not been seen in any form for several years in the athletic community. Just recently though it has shown up in a couple of new vet drugs from Australia; Spectriol and Drive. Methandriol itself is a high anabolic, high androgenic steroid. It is used for strength and weight gains. Some lifters feel it works well stacked with injectable testosterones. One claim is that it enhances receptor stimulation, causing the drug it is stacked with to bind better to androgen sites at the cell. Perhaps this is why the two new drugs previously mentioned are combination drugs. Methandriol will aromatise and it is moderately toxic. A popular counterfeit, Abolic injection or Metabolin claimed to be Methandriol dipropionate. It was quite abundant on the market, but has pretty much disappeared from the market at this time.

Steroid profiles | Anabolic / Androgenic Steroids| Methandriol - methylandrostenediol:
https://steroid.to/methandriol-methylandrostenediol

The possible side effects of Methandriol Dipropionate pills:

• The liver increase secretion
• The gastrointestinal affections
• The acne
• The ginaecomasthy
• An expanded aggressiveness
• An easy arterial tension increase

Roid Powers Blog:
http://roidpowders.blogspot.com/2016/11/what-is-methandriol-dipropyonate.html?m=0

Methandriol is a poor anabolic:
Methandriol dipropionate, used in some Australian veterinary products, is to be avoided by male bodybuilders. It is highly estrogenic, and has no redeeming properties. Methandriol is a poor anabolic and the mythical "receptor-cleaning" properties that have been claimed for it are pure fantasy. An anti-aromatase would not correct the estrogenic problems of methandriol dipropionate, since it is directly estrogenic, not requiring conversion by aromatase. An anti-estrogen such as Clomid would probably help, but since methandriol is a poor anabolic anyway, there is no point to a methandriol/Clomid stack.

Anabolic Steroids and Performance-Enhancing Drugs / Methandriol Dipropionate:
https://thinksteroids.com/steroid-profiles/methandriol-dipropionate/

Methandriol is rather unheard of:
Methandriol (MAD, as bodybuilders often refer to it) is a rather unheard of steroid for most people. For those familiar with the brief-lived popularity of prohormones as nutritional supplements, Methandriol's chemical name, "Methylandrostendiol" will sound more familiar . Methandriol is simply the prohormone 5-androstendiol, altered to be orally available. MAD is an Anabolic/Androgenic steroid which reportedly improves receptor affinity for/with other anabolic/androgenic compounds. This is why it has been added to several veterinary compounds, in small doses, such as Libriol, Drive, Spectriol, and Tribolan. It can provide good muscle gains along with good strength gains, and unfortunately causes high water retention as well. MAD 's supposed ability to "clean out" or potentiate androgen receptor sites is certainly possible (as other drugs have been known to increase androgen receptor concentration and number), but literature on it is scarce. In bodybuilding circles, this is it's claim to fame, however. Reportedly, long-term steroid users who had experienced so called receptor burn-out, or a possible decrease in receptor number or concentration were able to use MAD to renew gains. Recently, British Dragon has brought a solo Methandriol product to the market, and this is, at the time of this writing the only legitimate one being produced in the world today.

Thread: Methandriol Dipropionate (methyldrostenediol Dipropionate):
http://infinitymuscle.com/threads/40-Methandriol-Dipropionate-(methyldrostenediol-Dipropionate)

Primarily manufactured for use in veterinary medicine:
Methylandrostenediol is an anabolic steroid that gained popularity because of its reputation for putting on significant body mass to meat producing animals, with these results attempting to be reproduced by steroid users. The steroid utilizes 17 alpha alkylation as to better prepare the compound to resist being broken down by the liver when ingested orally. As stated, it is still primarily manufactured for use in veterinary medicine as a means to help increase weight gain in meat producing animals and was first marketed in the 1980s. For strength athletes and bodybuilders it is thought to produce weight gain in users when used in adequate doses, although these gains often result in both increases in muscle as well as water retention and body fat due to the unique characteristics of the compound.

Methandriol Dipropionate:
http://www.canadabodybuilding.com/showthread.php?6078-Methylandrostenediol-Methandriol-Profile

Methandriol is not really an actual steroid. It's more of a prohormone:
Its only illegal because it's either esterized or methylated, both practices declaring any steroidal substance illegal by the catch clause for schedule III drugs. But basically its 5-androstene-3beta, 17beta-diol, better known as 5AD. A prohormone that is legally available in pure form and a rather weak one at that. Being a prohormone it means it needs to interact with an enzyme to form the active substrate. In this case 5AD is a testosterone precursor, but it only yields about 0.19% of testosterone upon interaction with the 3beta hydroxysteroid dehydrogenase enzyme1 it uses to convert. So in terms of active anabolic compounds you see MAD is weaker than weak. Even in legal circles 5AD isn't really used very often because there are better substances available. So what's really the use of MAD? Well it seems 5AD is a potent estrogen agonist. That means it doesn't necessarily act as an estrogen and it certainly doesn't convert to an estrogen, but that it increases the effect of circulating estrogens from other compounds. This makes MAD quite capable of increasing bulk weight (water and/or fat) quite well when stacked with a substance that aromatizes heavily, such as methandrostenolone or testosterone.

Methandriol Dipropionate? (2004):
https://www.elitefitness.com/forum/anabolic-steroids/methandriol-dipropionate-336738.html

Methandriol Dipropionate:
https://juicedmuscle.com/jmblog/content/methandriol-dipropionate-0

Methandriol Monograph (PDF 5 pages):
http://www.swgdrug.org/Monographs/Methandriol.pdf

Methandriol Monograph:
http://www.inchem.org/documents/pims/pharm/pim906.htm

Methandriol dipropionate (MADP):
https://en.wikipedia.org/wiki/Methandriol_dipropionate

Adverse side effects include fluid and electrolyte retention, hypercalcaemia, increased bone growth and skeletal weight. In men, additional side priapism, azoospermia, hirsutism, male pattern baldness, acne andoedema. In women, side effects include virilization, amenorrhoea, menstrual irregularities, suppressed lactation, and increased libido. In children, side effects may include virilization symptoms. Metenolone may enhance effects of antidiabetics, ciclosporin, levothyroxine, warfarin. Resistance to the effects of neuromuscular blockers may occur, and metenolone also has the potential to interfere with glucose tolerance and thyroidfunction tests. Metenolone enanthate (methenolone enanthate) is an ester derivative of methenolone sold commonly under the brand names Primobolan (tablet form) orPrimobolan Depot (injectable). When it interacts with the aromatase enzyme it does not form any estrogens. It is used by people who are very susceptible to estrogenic side effects, having lowerestrogenic properties than nandrolone. This trait makes primobolan to be a good fat burner. Primobolan does not convert into estradiol.

As an anabolic steroid, the use of metenolone is banned from use in sports governed by the World Anti-Doping Agency. Belarusian shot putter Nadzeya Ostapchuk was stripped of her gold medal after testing positive for metenolone at the London 2012 Olympic Games. She has been excluded from future IOC events. The NBA and NBPA also banned the use of methenolone under the Anti-Drug Program. In February 2013, Hedo Turkoglu of the Orlando Magic was suspended for 20 games without pay by the league after testing positive for methenolone. In December 2013, Natalia Volgina was stripped of her 2013 Old Mutual Two Oceans Marathon title and received a two-year competition ban, subsequent to a final guilty verdict for using the steroid Metenolone.

Methenolone:
https://drugs.ncats.io/drug/9062ZT8Q5C

Began as a Starter Steroid:
Many beginners make first steroid experiences with methenolone. It is milder than many other steroids and has significantly fewer side effects. However, the weight gain and the increase in force are also significantly lower than by other steroids.

Metenolon was then much sought after and considered as a very mild steroid. In the end, it was not so mild and free of side effects, as we have seen today. For a long time, Metenolon was considered a starter steroid. For bodybuilders who have already had experience with stronger steroids, methenolone (neither in the acetate nor in the enatate form) is suitable neither for the build-up nor for the settling phase to maintain the muscle mass.

General experience of bodybuilders who have taken methenolone speak of a mass increase of just 3 - 4 kg in 6 weeks. The tablet version (metelonone acetate) is, however, discouraged, since the active ingredient is very poorly absorbed and is therefore no longer available for the purpose to be fulfilled. In order to achieve a better efficiency, body builders usually use the injection-variant (Methenolonenantat).

Methenolone acetate products (tablets) today come mainly from Japan and South Africa. Today, methenolonenate products (ampoules) come mainly from Mexico, Spain and Turkey.

Methenolone:
https://anabolika.de/en/methenolone

A mild nature:
Primobolan is nowhere near the most popular or powerful anabolic steroid on the market. But it is still popular, maybe for a different reason. The compound seems to hold potential for great results if used for the correct purpose. It is said to be one of Arnold Schwarzenegger's favorite steroids. You may conclude the benefits are obvious in that case if the rumors are true. Primobolan is a popular trade name of the anabolic and androgen steroid methenolone. This compound is familiar to many experienced steroid users, who often call it "Primo." It has a mild nature that makes it more tolerable to use compared to many other steroids. This drug is often compared to another popular anabolic steroid Anavar. But Primobolan is actually milder than Anavar. It has an androgenic rating between 44 and 57 and an anabolic rating of 88. Both ratings are even lower than those of testosterone.

Primobolan A Popular Steroid Amongst Athletes for Its Limited Side Effects:
https://www.gilmorehealth.com/primobolan-a-popular-steroid-amongst-athletes-for-its-limited-side-effects/

Anabolic Steroid:
Metenolone (or methenolone) is a long-acting anabolic steroid with weak androgenic (testosterone or androsterone-like) properties. It is a naturally occurring drug, found within the adrenal glands of pregnant domesticated felines, and is supplied as the acetate ester for oral administration and as the enanthate ester for intramuscular injection. Adult doses for the treatment of aplastic anemia are usually in a range of 1-3 mg/kg per day. Belongs to the class of organic compounds known as androgens and derivatives. These are 3-hydroxylated C19 steroid hormones. They are known to favor the development of masculine characteristics. They also show profound effects on scalp and body hair in humans.

Metabocard for Methenolone:
https://hmdb.ca/metabolites/HMDB0041928

What are Primobolan side effects/dangers?
Primobolan may be milder than other anabolic steroids and promise safer results; however, misuse - like with all things - can result in some pretty nasty side effects. Even though there aren't many scientific studies on the drug (aside from on rats), people who have used the steroid have reported many bad side effects. Common Primobolan side effects include: depression, acne, oily skin, hair loss/balding, excess body hair, increases in bad cholesterol, and gynecomastia (this usually only occurs if it has been stacked with another anabolic steroid). Obviously, if you keep to safe, lower dosages, the chance of these side effects happening should be minimal. However, we do advise leaning on the side of caution - especially if you are already predisposed to them e.g. you've got sensitive skin. Women especially should be careful.

Primobolan Depot Steroid (Methenolone) - Cycle, Dosage & Side Effects:
https://crazybulk.com/blog/primobolan-depot-methonolone

Primobolan Safety Data Sheet (PDF 6 pages):
https://www.caymanchem.com/msdss/17148m.pdf

Primobolan discussion:
https://thinksteroids.com/community/threads/lets-talk-about-primobolan.134381483/

Primobolan discussion:
https://canadianbrawn.com/threads/what-does-primobolan-metenolone-enanthate-do-for-you.814/

Primobolan discussion:
http://www.gymnation.co.nz/forums/topic/10131-primobolan-opinions-from-personal-experiences/

50+ results for Primobolan:
https://forums.t-nation.com/search?q=primobolan

#methenolone:
https://www.instagram.com/explore/tags/methenolone/?hl=en

Primobolan Package Leaflet (PDF 2 pages):
http://thecanadianpharm.com/images/products_images/primobolan.pdf

Metenolone esters are used mainly in the treatment of anemia due to bone marrow failure. Side effects of metenolone esters include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. Metenolone esters are synthetic androgens and anabolic steroids. They have moderate anabolic effects and weak androgenic effects, as well as no estrogenic effects or risk of liver damage. Metenolone esters were introduced for medical use in the early 1960s. In addition to their medical use, metenolone esters are used to improve physique and performance. The drugs are controlled substances in many countries and so non-medical use is generally illicit. They have mostly been discontinued for medical use and have limited availability.

Methylone:
https://drugs.ncats.io/drug/L4I4B1R01F

Methylone is sometimes used as a substitute for MDMA due to similarities in their effects. Alexander Shulgin commented that the substances has "almost the same potency of MDMA, but it does not produce the same effects." He also stated that it "has an almost antidepressant action, pleasant and positive, but not the unique magic of MDMA." The toxicity of methylone has not been well-studied, although it likely does not exceed that of MDMA, and it has a limited history of human usage.

Methylone Psychonaut Wiki:
https://psychonautwiki.org/wiki/Methylone

Similar to Ecstasy:
The designer drug 3, 4-methylenedioxymethcathinone, commonly known as methylone, is often found in the substances labeled as "bath salts." The chemical composition of methylone is very similar to the structure of MDMA (3, 4-methylenedioxymethamphetamine), and methylone is sometimes sold as Molly, suggesting that dealers are trying to pass it off as a substitute for ecstasy or similar drugs. Other street names for methylone include bubbles, explosion, MDMCAT, and ease. A number of research reports suggest that methylone use produces effects similar to MDMA and amphetamine. While the drug is a Schedule I controlled substance, it appears that its effects are not as well known as its use is not as extensive as similar drugs, even though the drug has been on the market for decades; it was originally developed in 1996 as a potential treatment for depression. Anecdotal evidence online from individuals claiming to have used the substance suggests that its effects can be somewhat varied and that its use is associated with a significant "crash" once the individual has stopped using the drug and its effects have begun to wear off.

Methylone Abuse: Dangers, Symptoms, and Treatment:
https://americanaddictioncenters.org/bath-salts-abuse/methylone

Street Names:
Meph, MC, MCAT, M-Cat, 4-MMC, Miaow, Meow Meow, Bubbles, Bounce, Charge, Drone, White Magic, Marzipan, Methylone

Effects:
Often described as a mix between Amphetamines, Ecstasy and Cocaine. Users feel alert, confident, euphoric and talkative, and some feel greater empathy with those around them. The effects last about an hour, but this can vary.

Drug form and method of use:
A fine white, off-white or yellowish powder - usually snorted like Cocaine or swallowed 'bombed' in wraps of paper. Can be smoked and in rare cases is injected. Also comes in capsules and pills.

Methylone (Cathinones):
https://www.ascert.biz/drug-and-alcohol-information/a-z-drugs/methylone-cathinones/

History:
The drug methylone first made an appearance in 2004 under the name 'Explosion' in a number of smart shops in the Netherlands. The product was advertised as a 'room odorizer' containing 5ml of the liquid drug. When the new product was first introduced, there was much confusion over what each bottle contained. It was not until January 2005 that the contents of 'explosion' was analysed. In March 2005 there was only one manufacturer and therefore this one sample analysis came to represent all 'Explosion' bottles, despite any further quantitative and confirmative data. The new drug gained a great amount of popularity after the Dutch radio presenter Giel Beelen took the drug during a live show.

Methylone (Cathinones):
https://www.release.org.uk/drugs/methylone/history

Methylone

Duration: bk-MDMA is a cathinone stimulant and empathogen, similar in structure to MDMA, though more stimulating and less empathogenic in comparison. Was very commonly mis-sold as MDMA on the street until it was banned in 2013. The Marquis reagent can differentiate bk-MDMA from MDMA. Less potent than MDMA with a slightly shorter duration.
Route	Onset	Duration	After Effects
Tripsit Factsheets
Methylone Basic Information: http://drugs.tripsit.me/methylone
All ROAs:	15-60 minutes	2-4 hours	6-24 hours
Marquis: Yellow

World Health Organization 2014:
Methylone ((3,4-methylenedioxy)methcathinone) is a synthetic cathinone. It is the beta-keto version of 3,4-methylenedioxymethylamphetamine (mdma). It was originally developed as a therapeutic for Parkinson's disease or depression by Shulgin. Use of methylone was first reported around 2005. Use/abuse has been reported from Japan, the USA and Europe. The effects and the mode of use reported have similarities with mdma, but its potency is less.

Reported toxic effects of methylone include tachycardia, hypertension, paranoia, anxiety, bruxism and muscle tension and aching. Some of these effects leeding to hospital admissions. A number of analytically confirmed drug-related deaths have been reported.

Animal studies have indicated that methylone possesses an abuse or dependence potential but there are no human clinical data to support this.

Methylone (bk‐MDMA) Critical Review Report (PDF 24 pages):
https://www.who.int/medicines/areas/quality_safety/4_14_Review.pdf

Methylone Reddit Search Results:
https://www.reddit.com/search/?q=methylone

The Big & Dandy bk-MDMA (Methylone) Thread (1000 comments):
https://www.bluelight.org/xf/threads/the-big-dandy-bk-mdma-methylone-thread.299732/

Tags - Methylone:
https://drugs-forum.com/tags/methylone/

Erowid Experience Vault:
https://erowid.org/experiences/subs/exp_Methylone.shtml

Methylone and me:
https://www.methylone.com/experiences/

Methylone (hydrochloride) Safety Data Sheet (PDF 5 pages):
https://www.caymanchem.com/msdss/10986m.pdf

Methylone Monograph (PDF 4 pages):
http://www.swgdrug.org/Monographs/Methylone.pdf

"Methylone" is also a trademarked brand name for an injectable form of methylprednisolone, a corticosteroid hormone used to treat arthritis and severe allergic reactions; hence, methylone may be confused with it. Aside from context, they can be distinguished by the fact that the name will usually be capitalized when referring to the prescription drug. A proposed alternate name is Bk-MDMA, or beta-keto-MDMA. While this nomenclature has not caught on because the name "methylone" became widely used before the conflicting Methylone trademark was noticed, the analogous names for related chemicals βk-MDEA and βk-MBDB have become the established names for those substances.

PMA was first encountered in the illegal drug market in the 1970s. Within a few years, PMA had been associated with several fatalities in Canada and subsequently earned the street name 'death'. PMA resurfaced in the 1990s in Australia and was again associated with a number of fatalities, particularly in South Australia. These deaths primarily occurred amongst people who thought they were consuming ecstasy.

PMA is also known as: 4-methoxyamphetamine, 4-MA, 'death', 'Dr Death'. Pure PMA is a white powder, but forms found on the street can also be beige, pink, or yellowish. It may knowingly be used on its own in order to increase the effects of MDMA; however, more often than not, PMA is sold as 'ecstasy' in either pill or capsule form. In these cases, it comes in a variety of different colours and with a variety of different logos, and is usually indistinguishable from ecstasy. This can be extremely dangerous since PMA has a higher potency (i.e. effects at lower doses) and a more delayed onset of activity than MDMA, and as such it is easier to overdose on PMA. High dosages of PMA can lead to sudden, large and potentially fatal increases in blood temperature, body temperature and blood pressure.

Paramethoxyamphetamine (PMA) Fact Sheet (PDF 1 page):
https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/NDA073%20Fact%20Sheet%20PMA.pdf

What it looks like:
PMA is sold as a pill but the pills can be lots of different colours and can have different marks on them. It is relatively easy to grind down pills to recolor and re-brand them with a new logo or design, so a pink heart-shaped pill can be made into a green round pill or a yellow square pill. As with any pill you can never be sure what it contains or how this might affect you.

Scottish PMA Facts:
https://knowthescore.info/drugs-a-z/pma/

PMA: not just another drug scare story:
PMA - the common name for paramethoxyamphetamine - is usually sold in pill form, sometimes stamped with a crown, or M and sometimes pink (hence the nickname "pink ecstasy"). People who take PMA often believe they are taking ecstasy. The drug's effects are similar but they can take up to an hour to be felt, so users may take another pill in the mistaken belief that the first has not worked, resulting in a massive dose.

"PMA is a potent releaser of serotonin," says Sumnall. "It also prevents the reuptake of serotonin back into neurons and inhibits the enzymes which are responsible for the breakdown of serotonin. This increase in serotonin, especially when PMA is taken in combination with other drugs, can lead to hyperthermia and subsequently, organ failure. Basically people are overheating and collapsing."

PMA: not just another drug scare story (2013):
https://www.theguardian.com/society/shortcuts/2013/jul/22/pma-not-another-drug-scare-story

Dr Death is often mistaken for ecstasy, but is more lethal:
Dr Death is also known as Pink Mitsubishi, PMA, Pink McDonalds, Pink Ecstasy, Killer, and Chicken Fever. The drug was first synthesised in 1967 by the psychedelic chemist Alexander Shulgin, the so-called godfather of MDMA. At the time he advised people to beware of the compound, according to Mike Power, author of Drugs 2.0. The drug is believed to have been first identified in the United States in the early 1970s.

What are its effects?
The drug has a similar high to MDMA, and can have psychedelic properties. It gives the user a buzz which makes sounds and colours feel more intense. It can also make a person feel like they have an intense affinity with those around them. But while Ecstasy can kick in after 20 minutes, it can take PMA up to an hour to begin working - sometimes leading people to fatally up their dose.

Dr Death is often mistaken for ecstasy, but is more lethal (2014):
https://www.independent.co.uk/life-style/health-and-families/health-news/dr-death-what-is-new-party-drug-and-what-are-the-risks-9644008.html

Effects of PMA and PMMA:
There is no safe level of drug use. Use of any drug always carries some risk. It's important to be careful when taking any kind type of drug.

PMA and PMMA affect everyone differently, but effects may include:

• Moderate stimulation
• Seeing colours and shapes
• Heightened senses (sight, hearing and touch)
• Dizziness
• Dry mouth and dehydration
• Increased bodily temperature - The most common cause of death from PMA is due to severe hyperthermia
• Increased perspiration teeth grinding
• Increased sweating
• Increased heartbeat and blood pressure
• Difficulty breathing
• Irregular eye movements
• Muscle spasms
• Decreased appetite
• Nausea and vomiting (common at any dose)
• Seizures - (more common with PMMA than with almost any other substance)

PMA and PMMA?:
https://adf.org.au/drug-facts/pma-and-pmma/

PMA can cause life-threatening side effects (such as hyperthermia and serotonin syndrome) even at moderate doses. As a result, using this substance is strongly discouraged. It is also advised to always test your MDMA for the presence of PMA using a reagent testing kit as it is a common adulterant.

PMA Summary Sheet:
https://psychonautwiki.org/wiki/PMA

Addictive:
As with ecstasy, it's possible to build up a tolerance (which means people need to take more PMA to get the same level of buzz). Psychological dependence may also develop (with an increased desire to keep taking the drug despite the risks). There have been no clear physical withdrawals reported with PMA but, as with ecstasy, users may feel lethargic or low for some days after having used.

How long does it stay in your system?
Shows up in urine tests for 3-8 days. (The length of time depends on the test used, the amount you take, if you have other medical conditions and your own metabolism. Please use this figure as a guide only).

PMA:
http://www.drugs.ie/drugtypes/drug/pma

EMCDDA - Europol Joint Report 2012:

• Twelve Member States as well as Croatia and Norway reported to Europol and the EMCDDA seizures of 4-methylamphetamine mostly in powder or paste form, ranging from 0.02 g up to 147 kg. A few seizures were in tablet or liquid form.
• Samples that contained 4-methylamphetamine typically contained amphetamine and caffeine in varying ratios.
• According to information provided to Europol, in recent years multiple illicit production sites and/or other indications related to the production of 4-methylamphetamine have been discovered in the Netherlands. Seizures related to international trafficking of 4-methylamphetamine have been reported by two Member States with indications of trafficking from a third Member State.
• According to information provided to Europol no distinct difference can be made between 4-methylamphetamine and amphetamine in terms of the involvement of organised crime groups, production, trade, and/or users.
• There is little evidence to suggest a specific demand for 4-methylamphetamine. However, the substance is sold as amphetamine (e.g. as 'speed'). Drug prevalence estimates suggest that about 12.5 million Europeans have tried amphetamines, and about 2 million have used the drug during the last year. Consequently, this population may be at risk of exposure to 4-methylamphetamine if this substance becomes more widely available.
• 4-methylamphetamine has no known medical use (human or veterinary) in the European Union.

4-MA Joint Reports (PDF 40 pages):
https://www.emcdda.europa.eu/system/files/publications/749/TDAS12001ENN_400433.PDF

PMA Experience Reports:
https://www.erowid.org/experiences/subs/exp_PMA.shtml

p-Methoxyamphetamine (PMA) Monograph (PDF 12 pages):
http://www.swgdrug.org/Monographs/p-METHOXYAMPHETAMINE.pdf

4-Methoxyamphetamine (hydrochloride) Safety Data Sheet (PDF 5 pages):
https://www.caymanchem.com/msdss/12041m.pdf

Alternate Names:
para-Methoxyamphetamine, beta-methoxyamphetamine

para-Methoxyamphetamine Drug Record:
http://www.dgidb.org/drugs/PARA-METHOXYAMPHETAMINE

Effects of PMA ingestion include many effects of the hallucinogenic amphetamines including accelerated and irregular heartbeat, blurred vision, and a strong feeling of intoxication that is often unpleasant. At high doses unpleasant effects such as nausea and vomiting, severe hyperthermia and hallucinations may occur. The effects of PMA also seem to be much more unpredictable and variable between individuals than those of MDMA, and sensitive individuals may die from a dose of PMA that a less susceptible person might only be mildly affected by. While PMA alone may cause significant toxicity, the combination of PMA with MDMA has a synergistic effect that seems to be particularly hazardous.