NANDROLONE

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Created Aug 2020

NANDROLONE

  • [DECA-DURABOLIN]
  • [DURABOLIN]
  • [DURABOLIN-50]

(17BETA-HYDROXYESTR-4-EN-3-ONE) | 19-nortestosterone

DEA CODE 4000: Schedule 3

Deca Durabolin is an extremely popular anabolic steroid comprised of the steroidal hormone Nandrolone and is attached to the large Decanoate ester. The Nandrolone hormone first appeared in 1960 and developed for commercial use in 1962 by Organon under the trade name Deca Durabolin. Since that time numerous Nandrolone Decanoate versions have hit the market, but Deca Durabolin remains the most recognized. This was not the first Nandrolone compound ever created, that would belong to Organon's Durabolin, which is specifically Nandrolone Phenylpropionate. The Phenylpropionate version is much faster acting with a less active duration, and while Phenylpropionate forms are popular, Deca Durabolin has largely dominated the Nandrolone marketplace.

Deca Durabolin is one of the most commonly used anabolic steroids among performance enhancing athletes. It is well known for being a tremendously beneficial off-season mass steroid, but it's also a favorite in many athletic circles for its therapeutic benefits. Due to its tremendous therapeutic benefits, the Nandrolone hormone is one of the most beneficial anabolic steroids in medical practice. However, due to years of anabolic steroid controversy such use has been quite limited in the U.S. for many years. Outside the U.S. Deca Durabolin remains a bit more popular in therapeutic treatment plans that can cover a host of areas.

Nandrolone drugs are used in the belief that they are capable in increasing muscle strength and size, increasing muscle hardness, and also decrease body fat. They additionally reduce the fatigue associated with training, and the time required to recover after physical exertion. Nandrolone is an anabolic steroid which are a group of drugs that are usually synthesized from the male reproduction hormone testosterone. Nandrolone belongs in the same class of banned substances as stanozolol, DHEA, testostrone and other anabolic steroids.

As a result nandrolone products (and other anabolic steroids) are banned by all sporting organizations to combat cheating and safe guard the health and safety of their sportsmen. By disturbing the body's equilibrium, anabolic steroids can potentially cause damage to many of the body's major organs, particularly the liver, which has to deal with breaking down the compound. There is also a significant risk of damage to the heart, which is made of muscle tissue. Anabolic steroids can lead to an expansion of the cardiac muscle, which can cause heart attacks. The drugs also promote the growth of bones, particularly facial bones such as the jaw, and the teeth. Other side effects include the development of inappropriate sexual characteristics such as breasts in men, and facial hair in women, a deepening of the voice, baldness and male impotence.
- http://www.3dchem.com/nandrolone.asp

Description:
Deca-Durabolin is an injectable form of the anabolic steroid nandrolone. Nandrolone is very similar to testosterone in structure, although it lacks a carbon atom at the 19th position (hence its other name, 19-nortestosterone). Like testosterone, nandrolone exhibits relatively strong anabolic properties. Unlike testosterone, however, its tissue-building activity is accompanied by weak androgenic properties. Much of this has to do with the reduction of nandrolone to a weaker steroid, dihydronandrolone, in the same androgen-responsive target tissues that potentiate the action of testosterone (by converting it to DHT). The mild properties of nandrolone decanoate have made it one of the most popular injectable steroids worldwide, highly favored by athletes for its ability to promote significant strength and lean muscle mass gains without strong androgenic or estrogenic side effects.

Nandrolone decanoate (ND) was first described in 1960, and became a prescription medication in 1962. It was developed by the international pharmaceuticals giant Organon, and sold under the brand name Deca-Durabolin. The name Deca-Durabolin denotes that the product contains a variant of Organon's previously popular nandrolone injectable Durabolin (nandrolone phenylpropionate), but using an ester of 10 carbon atoms. This greatly extends the release of nandrolone from the site of injection, such that ND lasts up to three weeks. With this advance, Organon expanded the market for nandrolone products rapidly. Probably owing to a combination of its favorable properties and the large market presence of Organon, Deca-Durabolin soon became one of the most widely distributed anabolic steroids in the world.

Depot Injection:
Deca Durabolin injection contains nandrolone decanoate in a peanut oil (arachis oil) base, which releases the active ingredient slowly over a period of up to three weeks. This is known as a "depot" injection. The injection is given into a muscle (usually the buttock) every three weeks.

Nandrolone is a C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of estradiol to resemble testosterone, but it has one less carbon atom at the 19 position (Pubchem). Nandrolone is an anabolic steroid occurring naturally in the human body, albeit in small quantities. Nandrolone is most commonly sold commercially as its decanoate ester (Deca-Durabolin) and less commonly as a phenylpropionate ester (Durabolin). Nandrolone use is indirectly detectable in urine tests by testing for the presence of 19-norandrosterone, a metabolism product of this molecule. The International Olympic Committee has set a limit of 2 ng per ml of urine as the upper limit, beyond which an athlete is suspected of doping.

NCI Dictionaries:
Nandrolone Decanoate:
The decanoate salt form of nandrolone, an anabolic steroid analog of testosterone with androgenic, anabolic, and erythropoietin stimulating effects. Nandrolone enters the cell and binds to and activates specific nuclear androgen receptors in responsive tissue, including the prostate, seminal vesicles, scrotum, penis, larynx, hair follicles, muscle, and bone. The resulting activated hormone receptor complex translocates into the nucleus and binds to androgen response elements (ARE) in the promoter region of targeted genes, where the complex promotes gene expression necessary for maintaining male sex characteristics. Mimicking the negative feedback mechanism of testosterone, nandrolone decanoate also suppresses the secretion of luteinizing hormone (LH). Furthermore, this agent also stimulates erythropoietin production by enhancing the production of erythropoietic stimulating factors.

Nandrolone Molecule of the Month - October 2000:
Nandrolone is an anabolic steroid that has recently caused a great deal of controversy after a number of big name athletes have been banned from competition after failing tests for this drug. These include Linford Christie, Mark Richardson and Dougie Walker (all well known British sprinters), Merlene Ottey (the Jamaican former 200 m world champion), and Dieter Baumann (the German 500 m runner). After protesting their innocence, all were subsequently cleared by their national athletics organisations, although the International Amateur Athletics Federation fueled the controversy further by overturning the reinstatement of Christie and Walker. As well as athletes, French soccer star Christophe Dugarry tested positive for nandrolone after a match last year, and following a Wimbledon quarter final in 1998 Czech tennis player Petr Korda also failed a test. But the fact that so many sportsmen have tested positive for the same substance in such a short space of time has led to speculation that the testing procedure may be flawed, or inaccurate. - http://www.chm.bris.ac.uk/motm/nandrolone/nandc.htm


Semisynthetic Anabolic-Androgenic Steroid:
Nandrolone, also known as 19-nortestosterone or 19-norandrostenolone, is a semisynthetic anabolic-androgenic steroid derived from testosterone. Nandrolone is used in the form of a variety of long-acting prodrug esters for intramuscular injection, the most common of which are nandrolone decanoate. Nandrolone decanoate is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Certain clinical effects and adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testis. Anabolic steroids have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. Synthetic version of nandrolone was developed in 1950. But nandrolone for sale appeared later only in 1962 in the form of decanoate under the trade name Deca-Durabolin

COMMON side effects:

If experienced, these tend to have a Severe expression:

  • A Condition In Which Women Develop Masculine Characteristics Called Virilism
  • Priapism, A Prolonged Erection Of The Penis
If experienced, these tend to have a Less Severe expression:
  • Acne
  • Bladder Contractions Causing The Need To Urinate Often
  • Breast Pain
  • Enlarged Breasts

Side Effects:
What are some side effects that I need to call my doctor about right away?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat
  • Signs of high calcium levels like weakness, confusion, feeling tired, headache, upset stomach and throwing up, constipation, or bone pain
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes
  • For women, no period
  • For females, a deep voice, facial hair, pimples, or period changes
  • More interest in sex
  • For males, erections (hard penis) that happen often or that last a long time
  • Shortness of breath, a big weight gain, or swelling in the arms or legs
  • Very bad headache

Interactions:

Drug Interactions (77) Alcohol/Food Interactions (1) Disease Interactions (10)


What other drugs will affect Deca-Durabolin?

A total of 77 drugs are known to interact with Deca-Durabolin.

  • 9 major drug interactions
    • anisindione
    • carfilzomib
    • dicumarol
    • leflunomide
    • lomitapide
    • mipomersen
    • pexidartinib
    • teriflunomide
    • warfarin
  • 68 moderate drug interactions

Pharmacokinetics:

  • Absorption:
    Well absorbed.
  • Distribution:
    Slowly released from I.M. depot following injection and is hydrolyzed to free nandrolone by plasma esterase.
  • Metabolism:
    Metabolized in the liver.
  • Excretion:
    Both the unchanged drug and its metabolites are excreted in the urine. The elimination half-life of nandrolone is 6 to 8 days.

Special considerations:
Administer nandrolone injections I.M. deep into the gluteal muscle. An adequate iron intake is needed for maximum response when patient is receiving nandrolone decanoate injections. Therapy should be intermittent, if possible. Monitor liver function test results, urine and serum calcium levels (in women with breast cancer), serum lipid and cholesterol levels, and CBC periodically. Prepubertal patients should have X-ray studies every 6 months to evaluate bone age. Duration of therapy depends on patient response and the occurrence of adverse reactions. Drug can cause abnormal results of fasting plasma glucose, glucose tolerance, and metyrapone tests; decreased 17-ketosteroid levels.

Breast-feeding patients:
It isn't known if anabolic steroids appear in breast milk. Because of the risk of serious adverse reactions in breast-fed infants, a decision should be made to discontinue breast-feeding or drug.

Pediatric patients:
The adverse effects of giving androgens to young children aren't fully understood, but the risk of serious disturbances (premature epiphyseal closure, masculinization of females, or precocious development in males) exists. Weigh the benefits and risks before starting therapy in young children.

Geriatric patients:
Assess elderly men for the development of prostatic hypertrophy and prostatic carcinoma.

GP2U PDF Nandrolone

EMC PDF Nandrolone

An androgen and anabolic steroid (AAS) which is used in the form of esters such as nandrolone decanoate (brand name Deca-Durabolin) and nandrolone phenylpropionate (brand name Durabolin). They are not used by mouth and instead are given by injection into muscle or fat. Side effects of nandrolone esters include symptoms of masculinization like acne, increased hair growth, voice changes, and increased sexual desire. They are synthetic androgens and anabolic steroids. Nandrolone esters have strong anabolic effects and weak androgenic effects, which give them a mild side effect profile and make them especially suitable for use in women and children. Nandrolone esters were first described and introduced for medical use in the late 1950s. They are among the most widely used AAS worldwide. In addition to their medical use, nandrolone esters are used to improve physique and performance, and are said to be the most widely used AAS for such purposes. The drugs are controlled substances in many countries and so non-medical use is generally illicit. Nandrolone itself and trenbolone are said to have among the highest ratio of anabolic to androgenic effect of all AAS.

Detection in body fluids:
Nandrolone use is directly detectable in hair or indirectly detectable in urine by testing for the presence of 19-norandrosterone, a metabolite. The International Olympic Committee has set a limit of 2.0 ug/L of 19-norandrosterone in urine as the upper limit, beyond which an athlete is suspected of doping. In the largest nandrolone study performed on 621 athletes at the 1998 Nagano Olympic Games, no athlete tested over 0.4 ug/L. Nandrolone was probably among the first AAS to be used as a doping agent in sports in the 1960s. It has been banned at the Olympics since 1974. There are many known cases of doping in sports with nandrolone esters by professional athletes.

  
How to Take Nandrolone and Dose of Nandrolone - Find out how to take Nandrolone (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed. Nandrolone should not be used in patients with ...
Monday December 15, 2014 - medindia.net

Nandrolone - Indications, Dosage, Side Effects and Precautions - Latest prescription information about Nandrolone. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions ...
Saturday May 20, 2017 - medindia.net

Who should not take Nandrolone Decanoate (bulk)? - The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is ...
Tuesday April 24, 2018 - webmd.com

Urine nandrolone metabolites: false positive doping test? - The abuse of the steroid testosterone presented a new problem for drug control in sport. 42 Perhaps the same can now be said for nandrolone. According to the Olympic movement anti-doping code, NA is ...
Monday August 23, 2021 - bjsm.bmj.com

The facts about nandrolone - When used in the body, nandrolone makes a waste product called 19-norandrosterone, which is released through the athlete's urine. Sometimes an athlete can have more nandrolone than normal in their ...
Saturday October 16, 2010 - news.bbc.co.uk

What should I Know Regarding Pregnancy, Nursing and Administering Depo-Nandrolone Intramuscular to Children or the Elderly? - management or monitoring precaution: General-Risk for prostatic hypertrophy or prostate carcinoma may be higher in elderly males.
Wednesday November 08, 2017 - webmd.com

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Sunday January 22, 2023 - outlookindia.com

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Friday January 27, 2023 - pharmabiz.com

Maha FDA raids Mumbai pharma co, seizes steroids, sex-boosters worth Rs 51L - In a swoop, the Maharashtra FDA has seized large stocks of over Rs 51 lakh of sex-enhancer drugs and steroid injections used for ...
Wednesday January 25, 2023 - glamsham.com

Simon Jordan insists Conor Benn can redeem himself like Tyson Fury and Canelo Alvarez, who bounced back after serving drug bans - Simon Jordan believes Conor Benn should be given the chance to redeem himself after failing two drug tests last year. ‘The Destroyer’ was due to face Chris Eubank Jr in October, but the fight was ...
Wednesday January 25, 2023 - talksport.com

Maharashtra FDA busts illegal steroids and sex booster drugs racket - Mumbai: The Maharashtra Food and Drugs Administration on Wednesday busted an illegal network of steroids used in gymnasiums and sex-booster drugs. On specific intelligence, officials laid a trap and ...
Wednesday January 25, 2023 - msn.com

FDA seizes steroids worth ₹51 lakh - The state Food and Drugs Administration (FDA) on Tuesday seized steroids and sexual performance enhancing drugs worth ₹51.27 lakh from an unlicensed supplier in Borivali ...
Wednesday January 25, 2023 - msn.com

  
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