Nordazepam is a 1,4-benzodiazepine derivative with amnesic, anticonvulsant, anxiolytic, muscle relaxant, and sedative properties. Nordazepam is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, pinazepam, and medazepam, used primarily in the treatment of anxiety disorders. Nordazepam is a partial agonist at the GABAA receptor, which makes it less potent than other benzodiazepines, particularly in its amnesic and muscle-relaxing effects. Nordazepam's elimination half-life is between 36 and 200 hours, with wide variation among individuals; factors such as age and gender are known to impact it. The variation of reported half-life are attributed to differences in nordazepam metabolism and that of its metabolites as nordazepam is hydroxylated to active metabolites such as oxazepam, before finally being glucuronidated and excreted in the urine. Common side effects of nordazepam include somnolence, which is more common in elderly patients and/or people on high-dose regimens. Hypotonia, which is much less common, is also associated with high doses and/or old age.

Nordazepam:
https://drugs.ncats.io/drug/67220MCM01

Definition:
An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.

Description:
Nordiazepam is a metabolite of Diazepam. Diazepam, first marketed as Valium by Hoffmann-La Roche, is a benzodiazepine drug. Nordazepam, also known as desoxydemoxepam, nordiazepam and desmethyldiazepam, is a 1,4-benzodiazepine derivative. Like other benzodiazepine derivatives, it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties.

Nordazepam:
https://selfdecode.com/chemical/nordazepam

Anxiety Treatment:
Nordiazepam, also known as desmethyldiazepam or dealkylprazepam, belongs to the class of organic compounds known as 1,4-benzodiazepines. These are organic compounds containing a benzene ring fused to a 1,4-azepine. Nordiazepam is a moderately basic compound (based on its pKa). Outside of the human body, nordiazepam has been detected, but not quantified in, a few different foods, such as common wheats, corns, and potato. This could make nordiazepam a potential biomarker for the consumption of these foods. A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety. Nordiazepam is a potentially toxic compound.

Metabocard for Nordiazepam:
https://hmdb.ca/metabolites/HMDB0060538

Nordazepam

Duration: Has all the normal benzodiazepine effects. Such as being an anti-convulsant, muscle relaxant, sedative effects, and anxiolytic. Active metabolite of Diazepam, Chlordiazepoxide, Clorazepate, among many others, which is where most of its effects come from. Has one of the longest lasting half-lifes in the class.
Route	Onset	Duration	After Effects
Tripsit Factsheets
Nordazepam Basic Information: http://drugs.tripsit.me/nordazepam
All ROAs:	45-120 minutes	10-20 hours	1-120 hours
Avoid: All other CNS depressants.

Main risks and target organs:
Central nervous system, causing depression of respiration and consciousness.

Nordazepam Monograph:
http://www.inchem.org/documents/pims/pharm/pim676.htm

Nordiazepam CRM Safety Data Sheet (PDF 6 pages):
https://www.caymanchem.com/msdss/ISO60174m.pdf

Contraindications and special caution:
Benzodiazepines require special precaution if used in the elderly, during pregnancy, in children, alcohol- or drug-dependent individuals, and individuals with comorbid psychiatric disorders. As with many other drugs, changes in liver function associated with aging or diseases such as cirrhosis, may lead to impaired clearance of nordazepam.

A benzodiazepine derivative. Nordazepam is among the longest lasting (longest half-life) benzodiazepines. Its elimination half life is between 36 and 200 hours, with wide variation among individuals; factors such as age and gender are known to impact it. The variation of reported half-lifes are attributed to differences in nordazepam metabolism and that of its metabolites as nordazepam is hydroxylated to active metabolites such as oxazepam, before finally being glucuronidated and excreted in the urine. This can be attributed to extremely variable hepatic and renal metabolic functions among individuals depending upon a number of factors (including age, ethnicity, disease, and current or previous use/abuse of other drugs/medicines). Nordazepam is a partial agonist at the GABAA receptor, which makes it less potent than other benzodiazepines, particularly in its amnesic and muscle-relaxing effects.