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CHLORPHENTERMINE
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Chlorphentermine exerts anorectic properties. It is a synthetic amphetamine derivative claimed to have none of the excitatory effects of the parent substance. PRE-SATE (Chlorphentermine HCl) is an effective appetite suppressant with a pattern of pharmacologic action substantially different from those of traditional anorexigenics. In providing dependable appetite control with appreciable loss of body weight, PRE-SATE does not significantly increase central nervous system (CNS), cardio respiratory or metabolic activity.
Chlorphentermine:
https://drugs.ncats.io/drug/NHW07912O7
Chlorphentermine is a stimulant drug which was used as an appetite suppressant. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine, which is still in current use. A relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.
http://www.chemeurope.com/en/encyclopedia/Chlorphentermine.html
- Chlorpheniramine relieves red, itchy, watery eyes; sneezing; itchy nose or throat; and runny nose caused by allergies, hay fever, and the common cold.
- Chlorpheniramine helps control the symptoms of cold or allergies but will not treat the cause of the symptoms or speed recovery.
- Chlorpheniramine is in a class of medications called antihistamines. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms.
- Chlorpheniramine comes as a tablet, a capsule, an extended-release (long-acting) tablet and capsule, a chewable tablet, and a liquid to take by mouth. Chlorpheniramine comes alone and in combination with fever and pain reducers, expectorants, cough suppressants, and decongestants.
- Nonprescription cough and cold combination products, including products that contain chlorpheniramine, can cause serious side effects or death in young children.
https://medlineplus.gov/druginfo/meds/a682543.html
Chlorphentermine:
It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use
- A serotonergic appetite suppressant of the amphetamine family
- Developed in 1962
- It's a derivative of the better known appetite suppressant phentermine
- It is not a psychostimulant and has little or no abuse potential
- The plasma half-life is about five days
- It was withdrawn from the market in the UK in 1974
Diagnosis | Endogenous lipid pneumonia - This pathologic feature is an uncommon complication induced by bleomycin and unique to this drug 3. However, in all the examined mouse lung sections, we did not observe airway obstruction. Tuesday January 09, 2024 - nature.com
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