The dealer did a brisk business, but three days after Christmas he permanently lost two of his customers, both Orange County men in their thirties. One was discovered comatose in a motel room and ticketed DOA at the hospital; the other died in his bathroom shortly after coming home from work. Heroin paraphernalia - needle, syringe, white powder - was found alongside both men, whose bodies bore the telltale needle marks of heroin mainlining.

Yet when forensic scientists screened the corpses for evidence of narcotic poisoning, they found no trace of heroin. Nor did tests of the white powders and syringe residues found near the victims yield any known drug.

China White and new heroin were not the first synthetic drugs to come from a clandestine lab - not by a long shot. Such labs have been illegally synthesizing LSD, PCP, amphetamine, methaqualone (Quaalude), and other drugs since the mid 1960s.

These drugs are extraordinarily cheap to synthesize. Less then $ 500 worth of chemicals and equipment can produce a cup of China White worth $ 2 million on the black market. And it takes only a modicum of laboratory experience to make the stuff from recipe. Theoretically, a single chemist could produce the equivalent of the entire world's supply of heroin without growing or harvesting a single opium poppy. And the designer market is not limited to heroin. Underground chemists can modify the molecular architecture of almost every drug on the illicit market to create legal substitutes. Why should organized crime continue to import heroin from Asia and cocaine from South America when they can make cheap and legal designer versions of them within our borders?

Continue Reading:
http://www.jackshafer.com/magazine_work/20091128_designer_drugs.php

• An opioid analgesic
• An analog of fentanyl
• Has similar effects to fentanyl - It is less potent yet longer acting
• Discovered in the 1960s
• In 1976, it began to appear mixed with china white heroin as an additive

It was first identified in the bodies of two drug overdose victims in Orange County, California, in December 1979, who appeared to have died from opiate overdose but tested negative for any known drugs of this type. Over the next year, there were 13 more deaths, and eventually the responsible agent was identified as alpha-methylfentanyl

alpha-methyl Thiofentanyl (hydrochloride) Safety Data Sheet (PDF 8 pages):
https://www.caymanchem.com/msdss/20821m.pdf

• An opioid analgesic
• An analog of fentanyl
• Was sold briefly on the black market in the early 1980s
• Has similar effects to fentanyl.

Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear

Ohmefentanyl is one of the most potent opioids known

So, a lethal dose of carfentanil would be approximately one-sixth the weight of a poppy seed.

But carfentanil isn't even the most potent fentanyl analog out there. That honor belongs to a satanic derivative called ohmefentanyl. 6.3 times more potent than carfentanil, 126-times more so than fentanyl, and 6,300 times more than morphine. This is just nuts. Doing the math, the estimated lethal dose of ohmefentanyl is 0.16 MICROGRAMS, which means that one poppy seed's worth of ohmefentanyl is enough to lethal dose 1900 people.

Excerpt from American Council on Science and Health:
https://www.acsh.org/news/2017/01/17/if-you-think-fentanyl-bad-10663

Ohmefentanyl is one of the most potent opioids known

• Ohmefentanyl is an extremely potent opioid analgesic
• 28 times more powerful as a painkiller than fentanyl (fentanyl is the chemical from which it is derived)
• 6300 times more powerful than morphine

Sold briefly on the black market in the early 1980's. Similar effects to fentanyl.

p-Fluorofentanyl solution:
https://www.sigmaaldrich.com/catalog/product/cerillian/f049?lang=en®ion=US

Parafluorofentanyl is a selective mu-opioid agonist, an analog of fentanyl, developed by Janssen. The drug was not developed for human use but is produced and abused illegally.

Parafluorofentanyl:
https://drugs.ncats.io/drug/I45R05QM0Z

Parafluorofentanyl

Duration: Rare, little known and extremely potent analogue of Fentanyl developed by Janssen Pharmaceutica in the 1960s. Use with extreme caution and never mix with other depressants.
Route	Onset	Duration	After Effects
Tripsit Factsheets
Parafluorofentanyl Basic Information: https://drugs.tripsit.me/parafluorofentanyl
Insufflated:	0-1 minute	2-3 hours	1-2 hours
Oral:	5-10 minutes	3-4 hours	1-4 hours
Aliases: pff 4-fluorofentanyl

WARNING This product is not for human or veterinary use.

para-Fluorofentanyl (hydrochloride) Safety Data Sheet (PDF 5 pages):
https://www.caymanchem.com/msdss/15496m.pdf

4-Fluorofentanyl was sold briefly on the US black market in the early 1980s. Side effects of fentanyl analogs are similar to those of fentanyl itself.

Thiofentanyl (hydrochloride) Safety Data Sheet (PDF 8 pages):
https://www.caymanchem.com/msdss/20786m.pdf

Thiofentanyl:

• An opioid analgesic
• An analogue of fentanyl

Thiofentanyl was sold briefly on the black market in the early 1980s, before the introduction of the Federal Analog Act which for the first time attempted to control entire families of drugs based on their structural similarity rather than scheduling each drug individually as they appeared.

Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening