It was used in medicine briefly during the 1960s and 70s, but has fallen out of clinical use.
Piminodine is an analog of pethidine. It was used in medicine for obstetric analgesia and in dental procedures briefly during the 1960s and 1970s, but has largely fallen out of clinical use. Piminodine produces analgesia, sedation and euphoria and has typical side effects associated with opioids, including potentially serious respiratory depression, which can be life-threatening. Piminodine was more potent than desipramine and protriptyline under similar conditions. Compared to meperidine, piminodine is more potent and gives smoother duration. Piminodine can be addictive. Piminodine is currently a Schedule II controlled substance in the United States.
- An opioid analgesic
- It's an analogue of pethidine (meperidine)
- It was used in medicine briefly during the 1960s and 70s, but has largely fallen out of clinical use.
It was used particularly for obstetric analgesia and in dental procedures and, like pethidine, could be combined with hydroxyzine to intensify the effects.
- The duration of action is 2 to 4 hours
- 7.5 to 10 mg via the subcutaneous route is the most common starting dose
- 7.5 to 10 mg being equal to:
- Oral formulations were also available.
- Piminodine has similar effects to other opioids, and produces analgesia, sedation and euphoria.
- Side effects can include itching, nausea and potentially serious respiratory depression which can be life-threatening.
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