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Created Apr 2019 | Updated Nov 2020



DEA CODE 9010: Schedule 2 Narcotic

There are two isomers of prodine: alphaprodine and betaprodine.

Alphaprodine is an opioid analgesic. It was used in obstetrics, as pre-operative medication, and for minor surgical procedures. In addition, this drug was used in the dentistry setting to help effectively manage pain associated with dental procedures.

Alphaprodine, also marketed under the brand name of Nisentil, is a narcotic pain reliver that is similar to morphine and pethidine. Often used for pain management in childbirth and labor as well as for other surgical procedures. In addition, it may be used in the dentistry.

As an opioid based drug, it can be highly addictive and result in adverse effects and medical complications.

Alphaprodine is a narcotic analgesic that is pharmacologically similar to morphine and meperidine, with the exception that it has a rapid onset and short duration of action. Alphaprodine acts primarily on the CNS and on smooth muscle. After intravenous administration, analgesia occurs in one to two minutes and lasts for 30 to 90 minutes. Following subcutaneous administration, analgesia usually occurs within 10 minutes and lasts for one to more than two hours.

Developed in Germany in the late 1940's. It was mainly used for pain relief in childbirth and dentistry, as well as for minor surgical procedures. Alphaprodine has a duration of action of 1 to 2 hours and 40 to 60 mg is equal to 10 mg of morphine.

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Created Feb 2019 | Updated Nov 2020


DEA CODE 9611: Schedule 1 Narcotic:

Betaprodine is an opioid analgesic under international control according to the UN Single Convention 1961. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures.

Prodine: (Betaprodine Redirects to Prodine)
Opioid pain reliever related to meperidine with an action similar to it but more rapid in onset and of shorter duration. It has been used in obstetrics, as pre-operative medication, for minor surgical procedures, and for dental procedures. Betaprodine is some 5x more potent than alphaprodine, but is metabolised more rapidly, and only alphaprodine was developed for medicinal use. It has similar activity to pethidine, but with a faster onset of action and shorter duration. Betaprodine produced more euphoria and side effects than alphaprodine at all dose levels and it was found that 5 to 10 mg of betaprodine equals 25 to 40 mg of alphaprodine.

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