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Created Jul 2019 | Updated Nov 2020



DEA CODE 2138: Schedule 4

Fospropofol is used to make a person relax or sleep (be unconscious) before and during surgery or procedures. This medicine is a strong sedative. A nurse or other trained health professional will give you this medicine in a hospital or surgery clinic. This medicine is given through a needle placed in one of your veins.

Appropriate studies have not been performed on the relationship of age to the effects of fospropofol in the pediatric population.

Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fospropofol in the elderly. However, elderly patients are more likely to have age-related heart disease, which may require an adjustment in the dose for patients receiving fospropofol.

Other Interactions:

  • Ethanol
  • Grapefruit Juice

Other Medical Problems:
Make sure you tell your doctor if you have any other medical problems, especially:

  • Breathing problems
  • Heart disease
  • Hypotension (low blood pressure)
  • Hypoxemia (low oxygen in the blood) - Use with caution. May make these conditions worse.

2010 Study:
Fospropofol (Lusedra) May Be An Alte ative to Propofol for Monitored Anesthesia Care
There may be compelling reasons to consider fospropofol as an alte ative sedative-hypnotic for MAC sedation procedures in adults where propofol is the preferred agent. There are significant differences in dosing routines, onset and peak sedation effects. Previous clinical trials and approved bolus doses of fospropofol provide a mild-moderate depth of sedation with minimal sedation-related adverse events. Larger initial bolus or supplemental dosing can increase the depth and speed of onset of sedation but will significantly prolong duration. Fospropofol's pharmacokinetic and effect differences may work well for certain MAC procedures and should require less frequent redosing during the procedure without the need for an infusion pump.

Precautions while using Fospropofol?

It is very important that your doctor check your progress while you are using fospropofol. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it.

Fospropofol may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert. You may also feel dizzy or lightheaded when getting up suddenly from a lying or sitting position, so get up slowly.

Fospropofol may cause your skin to itch and a side effect called paresthesias. This may cause bu ing, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings on your skin. Check with your doctor if you have these symptoms after receiving the injection.


Drug Interactions (92)

What other drugs will affect Fospropofol?

A total of 92 drugs are known to interact with Fospropofol.

  • 5 major drug interactions
  • 87 moderate drug interactions

Several water-soluble derivatives and prodrugs of the widely used intravenous anesthetic agent propofol have been developed, of which fospropofol has been found to be the most suitable for clinical development thus far. Purported advantages of this water-soluble chemical compound include less pain at the site of intravenous administration, less potential for hyperlipidemia with long-term administration, and less chance for bacteremia. Often, fospropofol is administered in conjunction with an opioid such as fentanyl.

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