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Created Feb 2019 | Updated Oct 2020



DEA CODE 9821: Schedule 1 Narcotic

Acetyl Fentanyl

Acetyl fentanyl is a relative of fentanyl and is five times more potent than heroin as a painkiller. The illegally produced compound may be secretly mixed with heroin to make it a more potent product, or may be sold in pills disguised as oxycodone. Users themselves may not be aware that they are ingesting it.

Acetylfentanyl is a synthetic opioid that was originally described in the 1960s. It's less potent than fentanyl and more potent than morphine. The drug has contributed to many fatalities, often due to it being mixed with heroin or misrepresented as heroin. In terms of effects, it appears similar to fentanyl.

Fentanyl has very euphoric properties, and is a favorite of drug abusers. Medical personnel abuse fentanyl in the parenteral form, but most street use comes from substituting fentanyl for heroin by drug dealers or from the illicit extraction of fentanyl from used or new transdermal patches. Recently, a close relative to medical fentanyl, acetyl fentanyl, has surfaced as a drug of abuse that has potentially fatal consequences.


Acetyl-Fentanyl is an opioid analgesic substance that is an analogue of Fentanyl. It's potency is roughly 6.67 times that of Morphine. Making it about 15 times less potent than its parent compound Fentanyl.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
All ROAs:5-20 minutes1-4 hours1-8 hours
Acetylfentanyl Duration
  • acetyl-fentanyl
  • a-f
Euphoria, Dry Mouth, Mood lift, Itchiness, Relaxant, Constipation, Pupil constriction, Analgesia.

World Health Organization 2015:
Acetylfentanyl is clearly being used for non-medical purposes,although the incidence and prevalence of its abuse cannot be accurately estimated because, in part, it is not routinely tested for in forensic toxicology. It has been identified in confiscated material being trafficked illicitly in the United States, Europe and Japan. It is sold over the Internet where it is sometimes promoted as a "research chemical", and its use is discussed on drug-user websites. Acetylfentanyl has been associated with at least 52 deaths in the United States (where it has been emergency scheduled under the Controlled Substances Act) and with deaths in Europe as well.

Users have reported using acetylfentanyl via insufflation, smoking, and through the intravenous routes of administration. Actual doses are thought to be in the microgram range. Effects reported by users appear indicative of heroin/fentanyl-like effects.

Acetylfentanyl is being controlled as an abused substance in some member states. Its use as an abused substance is unequivocal, and has resulted in several deaths. Precise estimates of the incidence and prevalence of acetylfentanyl's abuse, however, are difficult at present

Acetylfentanyl is a synthetic opioid. It is closely related to fentanyl, which is controlled under the United Nations Single Convention on Narcotic Drugs of 1961. Data suggests that acetylfentanyl is likely to be a potent opioid narcotic analgesic and may have an abuse liability and dependence potential in humans; these effects may be broadly comparable to fentanyl.Acetylfentanyl has been available in the European Union since at least 2013 and has been detected in 8 Member States and Norway. In most cases it has been seized as a powder, but other forms such as liquids and tablets have also been detected. The detected quantities are relatively small; however, there is still a cause for concern given the high potency of the substance. It appears that acetylfentanyl usually originates from chemical companies based China. There is no indication of illicit production sites within the European Union.

EMCDDA PDF Acetylfentanyl

  • An opioid analgesic
  • An analog of fentanyl
  • Estimated to be fifteen times more potent than morphine
  • It has never been licensed for medical use
  • It has been sold as a designer drug

Acetylfentanyl was discovered at the same time as fentanyl itself and had only rarely been encountered on the illicit market in the late 1980s. However, in 2013, Canadian police seized 3 kilograms of acetylfentanyl

Acetylfentanyl overdosage has been reported to closely resemble heroin overdosage clinically.

DEA informed about 52 confirmed fatalities involving acetylfentanyl in the United States between 2013 and 2015.

Three indicted in drug death of toddler Keynan Buxton - LAKE CHARLES, La. (KPLC) - Three people have been indicted in the death of a toddler who had methamphetamine-fentanyl and acetyl fentanyl in his system when he died. Keynan Buxton’s mother ...
Friday February 02, 2024 -

Federal grand jury indicts Buffalo man in drug case involving a toddler's death - Holloway also allegedly sold counterfeit M-30 oxycodone hydrochloride pills containing fentanyl and acetyl fentanyl ... of an investigation by the U.S. Drug Enforcement Administration, the ...
Sunday January 28, 2024 -

FIU pilot program aims to help law enforcement combat the opioid crisis - Florida International University launched a new and free program to get first responders trained in new devices that can detect powerful drugs without ever getting near them.
Thursday February 15, 2024 -

Coroner: Toddler died of ‘acute drug intoxication’ - (KPLC) - A toddler whose parents face manslaughter charges died of acute drug intoxication according ... had methamphetamine-fentanyl and acetyl fentanyl in his system. Coroner Terry Welke listed ...
Tuesday January 09, 2024 -

Man indicted for selling drugs that led to toddler’s death - BUFFALO, N.Y. (WIVB) — A Buffalo man was indicted for allegedly selling drugs that resulted in the ... containing fentanyl and acetyl fentanyl. The charge carries a minimum sentence of 20 ...
Monday January 29, 2024 -

Buffalo man facing drug charges in connection to death of a toddler - which caused the death of a toddler and sold counterfeit M-30 oxycodone hydrochloride pills containing fentanyl and acetyl fentanyl. The charges carry a mandatory minimum penalty of 20 years in ...
Sunday January 28, 2024 -

'The Voice' Contestant Nolan Neal's Cause of Death Revealed - The America's Got Talent and Voice alum died in July of "acute combined drug toxicity," after he ingested morphine, methamphetamine, fentanyl and acetyl fentanyl, an autopsy report obtained by ET ...
Thursday October 13, 2022 -

Federal grand jury returns the drug charges of a 23-year-old - Holloway also sold counterfeit M-30 oxycodone hydrochloride pills that contained fentanyl and acetyl fentanyl. Investigators for the case involved the Drug Enforcement Administration, under the ...
Monday January 29, 2024 -

Inmate facing felony charges for smuggling drugs into jail - 1, Ricketts allegedly admitted to her that she brought drugs into the jail. The victim, Evans, had both fentanyl and acetyl fentanyl in her system and the cause of death was a multi-drug overdose ...
Thursday September 07, 2023 -

Valley drug case set for federal jury trial - In addition, the defendants are charged with various counts of use of a communication facility in furtherance of a drug-trafficking ... fentanyl and acetyl fentanyl; possession with intent to ...
Monday September 06, 2021 -

Three indicted in drug death of toddler Keynan Buxton - LAKE CHARLES, La. (KPLC) - Three people have been indicted in the death of a toddler who had methamphetamine-fentanyl and acetyl fentanyl in his system when he died. Keynan Buxton’s mother, Summer ...
Friday February 02, 2024 -

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