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Created Feb 2019 | Updated Oct 2020




DEA CODE 7431: Schedule 1

5-MeO-DMT is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and a single psychoactive toad species, the Colorado River toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. It can also be found in the dart poison traditionally used by the Yanoama Indians of Upper Orinoco. It acts as a non-selective serotonin (5-HT) agonist. 5-MeO-DMT is classified as a controlled substance in China, Australia, Sweden, Turkey, and the USA.

5-MeO-DMT is a psychedelic of the tryptamine class, four to six times more powerful than its better-known cousin, DMT (N,N-dimethyltryptamine). It can be found in a wide variety of trees and shrubs, often alongside DMT and bufotenine (5-HO-DMT).

In Central and South America, some of the best known plant sources are Anadenanthera peregrina (yopo or cohoba) and Virola theiodora - both of which are traditionally harvested to make psychoactive snuff. It's also found in the milky white venom of the Bufo alvarius toad native to the southwestern United States and northwestern Mexico.

In its crystalline form, 5-MeO-DMT is often vaporized or snorted. Effects from vaporizing are usually felt within the first 30 seconds, peaking from 1-15 minutes and lasting for up to half an hour. A threshold dose is around 1-2 mg, while a moderate-to-strong dose is 5-10 mg.

Insufflated (snorted), it may take up to five minutes to feel the effects, despite the higher dose ranges involved (threshold: 3-5 mg; moderate: 8-15 mg). Effects tend to peak after 10-30 minutes and subside from around 30-45.

5-MeO-DMT may also be swallowed, taken sublingually (under the tongue), or injected. Much higher doses are required for swallowing and results can be unreliable.

5-MeO-DMT, which stands for 5-methoxy-n,n-dimethyltryptamine, is an extremely potent and intense psychedelic tryptamine. It's safety profile is pretty much like that of other psychedelics. Unlike it's illegal counterpart DMT, 5-MeO-DMT is not specifically scheduled (illegal) in the USA. However, its effects can be much more intense than DMT itself.

While DMT is more of a visual drug, 5-MeO-DMT is more of a "mindfuck" type drug. There are some visuals, but it is just basically like the universe imploding into your head, a huge mindfuck, which can be extremely scary or extremely blissful. The "place" where you go when you smoke it is often called The Void. This drug is the most common drug to cause ++++ (plus 4) experiences (see the Shulgin Scale in TiHKAL/PiHKAL). This drug will either make you shit yourself (not literally) in fear or give you an awesome blissful and transcendental experience (if you know how to handle it).

5-MeO-DMT is found in many natural sources, including many many plants and trees (There is usually DMT in the plant as well. Different species of different plants have different ratios/concentrations of these drugs). It is probably best known for being found in the Bufo Alvarius toad venom, along with 5-HO-DMT (AKA Bufotenine, which is not a pleasant psychedelic).

In its salt form, it can be snorted or injected. In it's more common freebase form, it is most often vaporized in a thin glass pipe, like methamphetamine. This leads to an intense psychedelic experience lasting 5-15 minutes, often accompanied by vomiting and muscle tremors. The dosage is 2-15mg in its freebase form. I would recommend starting your dose very low, so that you do not break through the first time. Also, ALWAYS make sure someone sober is with you and watching you (you move and shake a lot uncontrollably), ESPECIALLY if you do 10mg or more. Make sure your trip sitter grabs the pipe from you once you're done so you don't drop/break it.

Be careful, this is some crazy, crazy cosmic shit and only should be used by those with lots of psychedelic experience, in my opinion. Someone before me said that this drug is "foxy", which is actually 5-MeO-DiPT (which has EXTREMELY different effects, not even similar). It is not foxy, and if you get the two mixed up you will probably have a very, very bad experience. My friend smoked 15mg of 5-MeO-DMT freebase to his dome the other day. Another friend of mine and I had to physically restrain him for about 5-7 minutes, all the while he had vomited on himself and was screaming swear words at the top of his lungs. The whole time, his whole body was shaking violently from muscle tremors and we had to keep him from hitting his head on the wall. Once he came out of it, he thought that he was laying on my bed in peace the whole time, having a great trip.

5-MeO-DMT User's Guide (2010)
5-MeO-DMT is a profoundly powerful entheogenic compound. Its use can be radically life altering and should not be undertaken lightly or recreationally. Even highly experienced entheogen users are amazed and astounded by the 5-MeO-DMT experience and no amount of pr=iopr4 work with any other entheogen can prepare one for the magnitude of 5-MeO-DMT. For this reason, anyone considering personally experiencing 5-MeO-DMT should be informed to the fullest extent possible before embarking on such a radical experience. It is to this aim that this guide is written.


A powerful psychedelic tryptamine found in many species of plants and some toad venom, with a history of use by native South Americans spanning thousands of years. Has similar qualities to DMT and related tryptamines. Very potent. Orally active in combination with an MAOI.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
Insufflated:1-5 minutes15-45 minutes1-3 hours
Smoked:0-1 minutes5-15 minutes1-2 hours
5-MeO-DMT Duration
  • 5meodmt
  • toads
  • 5-meo
  • 5meo
  • 5-medmt
Smoked: short duration, powerful rushing of sensation, overwhelming fear, panic, experience of "the void", ego death

  • A psychedelic of the tryptamine class
  • It is a methoxylated derivative of DMT
  • It is found in a wide variety of plant species, and at least one toad species (the Sonoran Desert toad)
  • It has been used as an entheogen in South America.
  • First synthesized in 1936
  • It may have anti anxiety and anti depressant effects.

    The Church of the Tree of Life, founded in California in 1971 by John Mann but now defunct, declared the use of 5-MeO-DMT to be a sacrament. From approximately 1971 to the late 1980s, 5-MeO-DMT was discreetly available to its members.

  • Between 1970 and 1990 smoking of 5-MeO-DMT on parsley was probably one of the two most common forms of ingestion in the United States.

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