TILETAMINE AND ZOLAZEPAM
Tiletamine belongs to a class of drugs known as dissociative hypnotics, and is similar to phencyclidine (PCP). It works by disrupting the central nervous system and induces a cataleptic state. This drug does not provide muscle relaxation. Zolazepam alone provides only subtle evidence of its presence, unless high doses are given. However, when combined with tiletamine, a composite state of immobility, muscle relaxation, freedom from reflex movement, and analgesia prevails. This state provides conditions suitable for various diagnostic and therapeutic interventions, as well as for certain types of surgery.
Telazol serves as a rapidly acting general anesthetic that provides significant pain relief, immobility, and muscle relaxation. After intramuscular injection, the effects of Telazol are seen within 10 minutes. The effects after intravenous injection are seen within 1 minute. Due to its potential for abuse and misuse, Telazol is considered a controlled substance in some states.
Telazol (tiletamine and zolazepam for injection) is a nonnarcotic, nonbarbiturate, injectable anesthetic agent for dogs and cats. Chemically, Telazol is a combination of equal parts by weight of base of tiletamine hydrochloride, a dissociative anesthetic and zolazepam hydrochloride, a benzodiazepine with minortranquilizing properties. Telazol was developed as a combination product because tiletamine alone produces a variety of CNS effects including convulsions and muscle rigidity, whereas zolazepam produces belligerence in some individuals. Both effects have been identified as class effects for the individual drugs. The combination has been shown to produce dissociative anesthesia, to a degree not observed with either drug independently. Additionally, the adverse reactions listed above for each drug were eliminated or minimized when the two drugs were used in combination.
- I would imagine the fact that the only commercially available preparation includes with zolazepam is a large factor in the lack of diversion and widespread abuse.
- I know this has probably been stated earlier, but from my understanding Telazol is a compound product containing both zolazepam and tiletamine. The implications of this are that many trip reports about this substance referencing only tiletamine are probably descriptive of both the dissociative anesthetic and very potent benzodiazepine effects of the veterinary drug Telazol. Some of the Erowid reports seem indicative of a benzo blackout (constantly rediscovering that a friend is present as described in the "doggy k" report). So it is possible that few if any reports exist that describe solely the tiletamine experience. If anyone has any reports describing the experience of the pure chemical and NOT the drug Telazol I encourage you to share with the community.
- A pyrazolodiazepinone derivative structurally related to the benzodiazepine drugs
- Used as an anaesthetic for a wide range of animals in veterinary medicine
- Zolazepam is usually administered in combination with other drugs such as the NMDA antagonist tiletamine
- It is around four times the potency of diazepam
A 1:1 mixture of zolazepam and tiletamine is sold under the name Telazol.
Zolazepam, in combination with tiletamine, has been used in the tranquilization of wild animals, such as gorillas and polar bears, and has been found to be superior to ketamine because of reduced side-effects.
It is used in veterinary medicine in the combination product Telazol (tiletamine/zolazepam, 50 mg/ml of each in 5 ml vial) as an injectable anesthetic for use in cats and dogs.
- A dissociative anesthetic
- It is related chemically to ketamine
Telazol is the only commercially available tiletamine product in the United States.
Recreational use of telazol has been documented. Animal studies have also shown that tiletamine produces rewarding and reinforcing effects.
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