- Tenocyclidine (TCP) is a dissociative anesthetic drug with psychostimulant and hallucinogenic effects.
- This drug shows a broad spectrum of pharmacological activity including antidotal effect in organophosphorus compounds poisoning, radioprotective and anticancer effects.
- It was studied that the antidotal potency could protect acetylcholinesterase (AChE) in the case of organophosphate poisoning. However, the controversial role of TCP in brain protection should be studied further.
- Tenocyclidine has a high affinity for the N-methyl-D-aspartate (NMDA) receptors. This property allows using of TCP binding (association rate) as a marker of channel opening and thereby permitting measurement of NMDA receptor activation and ligand binding under identical conditions.
TCP was originally evaluated in 1960 as an intravenous (IV) anesthetic, as it appeared to display similar activity to PCP. However, research on TCP as a commercial drug for anesthesia was abandoned due to psychiatric side effects such as emergence delirium.
Case reports describe TCP as being slightly more potent than PCP by weight, with a longer duration. However, other reports state it is considerably more potent.
Extent of TCP Use:
In the 1970's there were reports of TCP found in street samples in Los Angeles, California and in Hawaii; however, by 1975, TCP and PCP use were reported in 25 states. In 1980, it was reported that TCP was sold on the streets as a white powder, but it has also been sold as tablets and on plant matter. Street sale and abuse of TCP, particularly in recent times, is not frequently cited.
PCP's powerful cousin: 3 things cops need to know about TCP:
- What is TCP?
TCP is short for tenocyclidine. Research was conducted on the drug as a treatment for traumatic brain injury and spinal cord injuries back in the 1970s. Now, it is a Schedule I drug that is not widely seen on the streets. By being categorized as Schedule I (the same category that heroin and LSD fall under, among others), the government has determined TCP has no medicinal value and it cannot be prescribed or possessed in the United States. TCP is a dissociative anesthetic and is much more potent than its chemical cousin, PCP. In fact, TCP has both stimulant and hallucinogenic properties.
- TCP potency:
TCP is almost 50 percent more potent than PCP. Hallucinations might be more amplified for the suspect on TCP than if he or she was on PCP. The subject's anxiety and paranoia may also be amplified.
TCP dissipates quickly from the blood, with a half-life of approximately two hours. TCP can be detected in the blood and urine if you must do a toxicology test in a criminal investigation. Detecting the presence of TCP depends on many factors including the individual's metabolism, body mass, age, hydration level, physical activity and health condition. However, TCP usually can be detected in the urine for two to five days, in the blood for up to 24 hours, in saliva for one to five days and in hair up to 90 days later.
- Signs and symptoms:
Individuals under the influence of TCP will have the same signs and symptoms as a person that is under the influence of PCP.
Estimating how long TCP (Tenocyclidine) is detectable in the body depends on many variables, including which kind drug test is being used. TCP - also known as N-[1-(2-thienyl)cyclohexyl] piperidine - can be detected for a shorter time with some tests but can be "visible" for up to three months in other tests. The timetable for detecting TCP in the system is also dependent upon each individual's metabolism, body mass, age, hydration level, physical activity, health conditions, and other factors, making it almost impossible to determine an exact time TCP will show up on a drug test.
The following is an estimated range of times, or detection windows, during which TCP can be detected by various testing methods:
TCP can be detected in the urine for 2-5 days.
A blood test can detect TCP for up to 24 hours.
A saliva test can detect TCP for up to 1-5 days.
TCP, like many other drugs, can be detected with a hair follicle drug test for up to 90 days.
- Generally just used in research into NMDA receptor.
- Too potent for recreational use, and seemingly incredibly difficult to aquire anyway.
- Its Activity as a dopamine reuptake inhibitor would promote even more reckless behavior than PCP does (and we all know that can result in nightmare situations).
- Frankly It sounds like one of those dissociatives thats better uses as a chemical weapon than a recreational drug. Dissociatives need to cripple you, because christ, the shit you'd get up to if you were both tweaked and on one, it could and would only end one way.
- A dissociative anesthetic drug with psychostimulant and hallucinogenic effects
- Discovered in the late 1950s
- Similar in effects to phencyclidine (PCP) but is considerably more potent.
Due to its similarity in effects to PCP, TCP was placed into the Schedule I list of illegal drugs in the 1970s, although it was only briefly used in the 1970s and 1980s and is now little known.
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