TALBUTAL

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Created Feb 2021

TALBUTAL

  • [LOTUSATE]

DEA CODE 2100: Schedule 3

Lotusate

Lotusate

  • Here we have a bottle of Lotusate (talbutal) by Winthrop. It is a much rarer barbiturate than the classics of Seconal, Pentobarb, etc. Per some reports, and clinical literature, it has a body high and euphoria that far exceeds even Seconal & Pentobarbital, with a longer duration of action. The caplets are a very attractive purple color, and they are dosed at 120mg per caplet.

Old Lotusate Bottle

Image #1 from: Lotusate (Talbutal) by Winthrop - a rare Barbiturate more euphoric than Seconal & Pentobarbital:
https://www.reddit.com/r/ObscureDrugs/comments/k79nzy/lotusate_talbutal_by_winthrop_a_rare_barbiturate/
Image #2 from: Lotusate AKA Talbutal The Ultimate Barbiturate!:
https://www.reddit.com/r/DrugMuseum/comments/hoimoz/lotusate_aka_talbutal_the_ultimate_barbiturate/

  • No Longer Marketed:
    Lotusate is the brand name for the generic talbutal, one of the barbiturates with a short to immediate duration of action. It is a Schedule III Controlled Substance in the United States. Lotusate is no longer available directly from the manufacturer and is likely only found on the street.
  • Central Nervous System Depressant:
    As a barbiturate, Lotusate acts as non-selective depressant of the central nervous system (CNS) and is capable of producing all levels of mood alteration from excitation to mild sedation, hypnosis and deep coma. Lotusate will also induce anesthesia when delivered in sufficiently high doses.
  • Similar to Alcohol High:
    As a barbiturate, Lotusate could easily be known as a brain relaxer, much like alcohol. The effects of both on the brain are very similar. People will often use barbiturates such as Lotusate to try and achieve the same "high" they can generally achieve with alcohol intoxication. In attempting this high with Lotusate, the person is at increased risk as the window between the dose causing drowsiness and the one causing death can be very small.
  • Addiction:
    Whenever Lotusate is taken for longer than just a couple of weeks or when taken recreationally for non-medical purposes, addiction can easily emerge. Such users tend to take more than the safe amount to achieve a desired "high", resulting in abuse of the drug. Over time, the brain develops a need for Lotusate, making it very difficult for the user to function without it.
  • Tolerance and Withdrawal:
    Lotusate depresses the respiratory and nervous system functions, therefore it increases the risk of building a tolerance to the drug very rapidly. For a person who is dependent or addicted to Lotusate, withdrawal symptoms can occur 12-20 hours after the last dose and remain for several weeks or even months.

Lotusate Definition:
https://www.addiction.com/blogs/a-z/lotusate/

Talbutal is a short to intermediate-acting barbiturate, which had been used under brand name Latusate as a sedative and hypnotic, but then this usage was discontinued. It was found, that talbutal binds at a distinct binding site at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. Thus the post-synaptic inhibitory effect of GABA in the thalamus is therefore prolonged.

Talbutal:
https://drugs.ncats.io/drug/4YIR8202AX

  • Talbutal is only found in individuals that have used or taken this drug.
  • Belongs to the class of organic compounds known as barbituric acid derivatives.

Metabocard for Talbutal:
https://hmdb.ca/metabolites/HMDB0014451

  • Short to intermediate acting compounds are used principally as sedative-hypnotic agents.
  • Barbiturate with intermediate duration of action. Following usual hypnotic dose, onset of sleep occurs in 15-30 min & lasts from 6-8 hr. Dose - usual hypnotic, 120 mg before bedtime; sedative, 30 mg 2 or 3 times daily.
  • Short-term treatment of insomnia; however, talbutal generally has been replaced by benzodiazepines.
  • Short-acting barbiturate, on set of action 10-15 min; duration of action 3-4 hr.

Technical details about Talbutal, learn more about the structure, uses, toxicity, action, side effects and more:
https://www.pharmacompass.com/chemistry-chemical-name/talbutal

Alternate Names:
  • LOTUSATE
  • TALBUTAL
  • 5-ALLYL-5-SEC-BUTYLBARBITURIC ACID
  • TALBUTALUM
  • TALBUTALE
  • SEC-BUTYL ALLYL BARBITURIC ACID
  • (RS)-5-ALLYL-5-SEC-BUTYLPYRIMIDINE-2,4,6(1H,3H,5H)-TRIONE
  • chemidplus:115-44-6
  • chembl:CHEMBL1200802
  • pubchem.compound:8275
  • rxcui:89810
  • drugbank:00306

Talbutal Drug Record:
https://www.dgidb.org/drugs/TALBUTAL

  • A barbiturate
  • Short to intermediate duration of action
  • A structural isomer of butalbital

https://en.wikipedia.org/wiki/Talbutal

https://pubchem.ncbi.nlm.nih.gov/compound/talbutal

https://www.drugbank.ca/drugs/DB00306

  
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