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Created Dec 2020


  • [PCA]


DEA CODE 7460: Schedule 2

PCA (1-phenyl cyclohexylamine) as a precursor for either PCP or other analogs. PCA itself is an active compound, and has been under clinical study as a potential anesthetic agent. It is approximately one half as potent than PCP and appears to have similar actions. PCA can be transformed into other PCP analogs by alkylation of the amino group by a number of methods.

1 phenycyclohexylamine, a pcp precursor and dissociative drug:

  • All i can find on this stuff is that it's a chemical precursor to PCP and that it is a dissociative drug itself. Potency is said to be 1/2 that of PCP. It's also known as PCA. PCA and analogs if PCA have been investigated as anticonvulsants and anaesthetics. A term that keeps coming up in studies of PCA and analogs is "motor toxicity". From what I gather, this means the animals the drugs were administered to had impaired motor functioning while on the drugs (a characteristic of dissociatives) and he motor impairment is correlated with activity at the pcp receptor. This stuff is readily available online. Anyone know anything about it? Any brave guinea pigs? It is considered a pcp precursor in California, and if you are in possession of PCA with any other pcp reagent, like phenyl magnesium bromide, you can get charged with pcp manufacturing. If you have pca alone you are fine. I have no idea if this is a watched chemical. If it's anything like pcp, but only weaker, it could be a great legal pcp alternative
    • It appears PCA is a metabolite of PCP and may be responsible for some of the dopamine agonist/release/reuptake inhibition

      The effect of phenylcyclohexylamine (PCA) on the efflux of dopamine (DA) in the neostriatum was examined using in vivo electrochemical techniques. Phenylcyclohexylamine produced a long-lasting dose-dependent biphasic effect on the efflux of DA in the rat. This response, to one of the major metabolites of phencyclidine, was similar in duration to but less potent than that seen with phencyclidine.

Low Motor Toxicity Summary:
1‐Phenylcyclohexylamine (PCA) and its analogues 1‐phenylcyclopentylamine (PPA) and 1‐(3‐fluoropheny1)cyclohexylamine (3‐F‐PCA) are potent anticonvulsants in the mouse maximal electroshock (MES) seizure test. Unlike the structurally related dissociative anesthetic phencyclidine (PCP), however, which produces motor toxicity at anticonvulsant doses, PCA, PPA, and 3‐F‐PCA protect against MES seizures at 2.2‐ to 3.5‐fold lower doses than those that cause motor toxicity when administered intraperitoneally

Belongs to the class of organic compounds known as aralkylamines.

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