MT-45 is an opioid that's been used for a few years, with it primarily coming from online research chemical providers. The drug does have some pleasant opioid effects, but it's usually not described as an ideal and truly enjoyable drug. Other opioids are almost always preferred. It was developed in the 1970s by a Japanese pharmaceutical company. Outside of a small amount of research in animals, it has little/no history prior to the early 2010s. Since 2013, online vendors have sold it and reports of its effects have grown.

While MT-45 has been used like other RC opioids, most users tend to abandon it upon finding it has too many negative effects and/or too few positive effects relative to other drugs. So long as a common dose is used, it doesn't appear to be particularly harmful acutely. But, reports of persistent hearing loss and possible hair loss suggest it's not wise to use on any regular basis or at strong+ doses, which applies to many RCs in general.

December 19, 2016

CLUBBERS' FORMER LEGAL HIGH MAY LEAD TO BLINDNESS:
MT-45 was used as a painkiller in the 1970s before it was used as a legal high and ultimately banned in 2015. From BathChronicle by James Crawley | Katherine Clementine

A now banned legal high can cause clubbers' hair to fall out, painful rashes and may even caused blindness, doctors have warned. Health experts say taking MT-45, developed as a painkiller in the 1970s but now considered a Class A drug, left some users needing cataract surgery in both eyes. Researchers at the Karolinska Institutet in Sweden found that the drug, which was banned in the UK in 2015, can be bought illegally online from at least 17 websites. Three Swedish men, aged between 23 and 34, all suffered the same unusual symptoms after taking MT-45, according to a new study. First their hair lost colour and began falling out, before painful, raw rashes covered their whole bodies. In the year after taking the drug two men rapidly developed severe sight loss and needed cataract surgery, leading to a stark warning from medical experts.

Matthew Gass, of the British Association of Dermatologists, said: "MT-45 is a class A drug, and that in and of itself, should warn potential users to avoid it. "However, on top of this we have seen a number of similar, serious, adverse reactions to the drug, some clinically proven and some anecdotal. "This suggests that MT-45 is either itself profoundly toxic, or that there is a problem in the MT-45 supply chain that is causing this complex and unusual combination of symptoms. "Either way, it is important that patients and healthcare professionals are aware of the potential for MT-45 to leave users blind, bald and covered in painful skin complaints. "I would urge anyone currently using this drug to stop immediately and consider getting medical attention."

Study author Professor Anders Helander, of the Karolinska Institutet in Sweden, said: "The escalating online availability and use of hundreds of unclassified new psychoactive substances has become a growing health problem worldwide. "Most new substances have not been tested on humans, increasing the risk for harmful and unexpected adverse events and overdose deaths. "Another risk factor is that the substances are typically manufactured in clandestine laboratories with no product control. "The number of medical complications and deaths due to these drugs is constantly increasing, and the cases associated with MT-45 are one serious example." Originally developed as a painkiller, MT-45 was used as legal high by 2013, before Psychoactive Substances Act came in to force, banning all drugs previously considered 'legal highs.'

World Access for the Blind:
https://www.facebook.com/worldaccessfortheblind/posts/even-though-mt-45-is-banned-its-still-out-there-its-one-high-not-worth-going-bli/10153963528687273/

MT-45

Duration: A synthetic opioid drug that was rumoured to be roughly 80% the potency of Morphine orally. Was created by Dainippon Pharmaceutical in the 1970's. It has been used as a lead compound for the design of related substances. It has been associated with hearing loss and hair loss. Structurally unrelated to most other opioid drugs. Treat with caution, especially long term use.
Route	Onset	Duration	After Effects
Tripsit Factsheets
MT-45 Basic Information: http://drugs.tripsit.me/mt-45
All ROAs:	30-45 minutes	4-6 hours	2-3 hours

EMCDDA - Europol Joint Report 2014:

• MT-45 is a synthetic opioid.
• It has been available in the EU since at least October 2013 and has been detected in three Member States: Belgium, Germany and Sweden.
• In most cases it has been seized in small quantities as a powder.
• Over a short period of time MT-45 has been associated with 13 non-fatal intoxications and 21 deaths in Sweden.
• MT-45 is similar to morphine in some aspects of its pharmacology, although in some animal studies it exhibited a higher toxicity than morphine.
• There has been one case where MT-45 was detected in a seized sample of brown heroin base.

MT-45 Joint Reports (PDF 17 pages):
https://www.emcdda.europa.eu/attachements.cfm/att_230615_EN_TDAS14007ENN.pdf

MT-45 is an opioid analgesic drug invented in the 1970s. Structurally unrelated to most other opioid drugs. MT-45 has around 80% the potency of morphine. MT-45 has been used as a lead compound from which a large family of potent opioid drugs have been developed, including full agonists, partial agonists, and antagonists at the three main opioid receptor subtypes.

Recreational use of MT-45 has been associated with hearing loss and unconsciousness.