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Created Sep 2019 | Updated Oct 2020


  • [SONIN]

DEA CODE 2773: Schedule 4

Loprazolam is a hypnotic drug which stimulates GABA-A receptors. Due to its hypnotic activity the drug is used to treat short-term sleep disorders.

Loprazolam is a type of medicine called a benzodiazepine. Benzodiazepines are used for their sedative, anxiety-relieving and muscle-relaxing effects. Loprazolam is used for the short-term (two to four weeks only) treatment of severe insomnia that is disabling or subjecting the individual to extreme distress. It decreases the time taken to fall asleep and number of times you wake in the night, as well as increasing the total amount of time spent sleeping. However, it is only suitable for short-term treatment of insomnia as it has a high potential for dependence and addiction.

Loprazolam works by acting on receptors in the brain called GABA receptors. This causes the release of a neurotransmitter called GABA in the brain. Neurotransmitters are chemicals that are stored in nerve cells in the brain and nervous system. They are involved in transmitting messages between the nerve cells. GABA is a neurotransmitter that acts as a natural 'nerve-calming' agent. It helps keep the nerve activity in the brain in balance, and is involved in inducing sleepiness, reducing anxiety and relaxing muscles. As loprazolam increases the activity of GABA in the brain, it increases its calming effect and results in sleepiness, a decrease in anxiety and relaxation of muscles.

Loprazolam 1mg Tablets is prescribed to treat short term sleep problems in adults such as: difficulty falling asleep and waking frequently during the night. This medicine can only be obtained with a prescription. Loprazolam 1mg Tablets is used for short term sleep problems and is not meant to be used every day for long periods of time. It is recommended that this medicine should be taken, whole with a drink of water, just before bedtime. Loprazolam 1mg Tablets should not be taken for more than 4 weeks. Loprazolam 1mg Tablets belong to a group of medicines called hypnotics. This medicine works by acting on your brain, to help you sleep.

Loprazolam is a sedative hypnotic benzodiazepine medication and is indicated for the treatment of short term insomnia. It should be administered immediately before bedtime. Note that loprazolam remains active in the body for many hours and drowsiness may occur the next day. This benzodiazepine should in most case not be used for longer than 2-4 weeks, as tolerance and physical and psychological dependence can occur. Loprazolam shares with other benzodiazepines the risk of abuse, misuse, psychological and/or physical dependence. If prescribed for longer than 4 weeks your doctor should periodically reassess the need for loprazolam.

  • Overdose risk: High.
  • Dependence risk: High.
  • Is loprazolam available as a generic? No.
  • Is loprazolam available as prescription only? Yes.
  • Onset of effect: Within 30 minutes.
  • Duration of action: Up to 12 hours.
  • Tolerance has been noted with long-term use.
  • Pregnancy: Avoid.
  • Potential risk to the fetus has been reported.
  • Breastfeeding: Avoid.
  • This medication is passed through breast milk and may affect your baby adversely.
  • Driving and hazardous work: This medication should be avoided as it may cause extreme sedation.
  • Do not consume alcohol while taking this medication, as side effects may be drastically pronounced.

Loprazolam works by affecting the way certain brain chemicals (neurotransmitters) transmit messages. This has a calming effect which helps you to sleep. It works well in the short term, with one week's treatment normally being sufficient, although up to three weeks of treatment are sometimes required. If you take it for longer, the medicine may lose its effect (you may become tolerant to the effect) and when you stop taking it you may develop withdrawal symptoms. You may need to keep taking the medicine to avoid the withdrawal symptoms. This is known as drug dependence. The effects of loprazolam can last into the following day; please be aware that it is likely to impair your judgement and reactions, and so affect your ability to drive.


Has all the classic benzodiazepine effects. Is usually only prescribed for a short amount of time for insomnia.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
All ROAs:30-50 minutes6-10 hours1-8 hours
Loprazolam Duration

It was patented in 1975 and came into medical use in 1983. Hypnotics should only be used on a short-term basis or in those with chronic insomnia on an occasional basis. The dose of loprazolam for insomnia is usually 1 mg but can be increased to 2 mg if necessary. In the elderly a lower dose is recommended due to more pronounced effects and a significant impairment of standing up to 11 hours after dosing of 1 mg of loprazolam. The half-life is much more prolonged in the elderly than in younger patients. A half-life of 19.8 hours has been reported in elderly patients. Patients and prescribing physicians should, however, bear in mind that higher doses of loprazolam may impair long-term memory functions.

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