GLUTETHIMIDE

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Created Jul 2019 | Updated Nov 2020

GLUTETHIMIDE

  • [DORIDEN]
  • [DORIMIDE]
  • [ELRODORM]
  • [NOXYRON]

DEA CODE 2550: Schedule 2

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Drug-enforcement officials and medical authorities say an inexpensive and hazardous substitute for heroin has gained popularity among addicts.. The substitute, known to addicts as loads, consists of two prescription-drug tablets taken together - identified as glutethimide, a hypnotic sedative that is sold as Doriden, and a combination of aspirin phenacitin, caffeine and codeine, a pain killer. It's a particularly vicious combination. The drugs, which are safe when prescribed individually, act as a severe depressant to the nervous system when combined and can be dangerous for the user, medical authorities say. The prescription drug combination is taken orally, the officials say, and it produces a comparable high to heroin for the user.

Drugs-Forum Codeine and Glutethimide:

  • According to Wikipedia 'glutethimide is an enzyme-inducer. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) in to morphine.' and apparently 'in 1991 it was upgraded to Schedule II, more than a decade after recreational abusers discovered that combining the drug with codeine produced a euphoria which closely resembles that obtained from heroin.'

    • the combo, as said on Wikipedia and elsewhere is called 'Fours and Dors' [coming from the old brand name Doriden] and also pancakes and syrup, because the codeine was often in the form of cough syrup. The pills were made by Ciba, and because that was written on them, some people called them 'cibas'.

      • The Cibas and codeine were big in the 80s I remember my friend's sister was big into them, they were called "hits" or Cibas n codeines". She got them in Paterson and I think they were like $30 a pop for the two pills. I tried them a couple of times and I clearly remember they were NOT as good as the heroin that was available back then which was a much, much better product then what's being sold on the street now. I would say it was about the same effect as taking a couple blues/one Oxy orally.

        • On the west coast they were called "Loads" or "Dor's and 4's. The Doriden really did potentiate the Codeine. I guess the once the gov't found out people liked them (and there was a high potential for abuse) they figured there were too many other safer alternatives and so they made Ciba halt production.

Bluelight Forum Glutethimide Experiences:

  • The cool thing about glutethimide is that in addition to being a strong downer in it's own right, it induces CYP2D6 like you said, and blocks the primary way opiates are metabolized by glucuronidation at the 3-hydroxy to the inactive morphine-3-glucuronide. This means that in addition to making codeine stronger, it makes it last much longer too. It might work for other opiates too, even non-prodrugs like morphine or hydromorphone.

    The downside is I think it's about as toxic as amobarbital when adjusted for potency differences, and it metabolizes into something twice as strong. Although I don't think it has barbs' fuck up tolerance pattern, where the tolerance to the euphoria rises faster than to the toxicity, the lethal dose(2 grams) never rises above twice the non-tolerant lethal dose, and the tolerance to the euphoric effects levels off at 1.5 grams, leaving a razor thin line between feeling good and death. Could be wrong about that with Doriden.

    • Glutethimide (Doriden) was special because it induced a liver enzyme that made codeine way stronger and longer lasting. Like I said before it was pure euphoric long lasting bliss.

      • For the record guys, I would be really surprised if we find someone who has actually taken this recently. I've been to some pretty shadowy pharmacies around the world in my life

Glutethimide is a GABA agonist that was introduced by Ciba in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms. Glutethimide was discontinued in the US by manufacturers in 1993. Current production levels in the United States point to it only being used in small-scale research.

Glutethimide is only found in individuals that have used or taken this drug. It is a hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem] Glutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination. This compound belongs to the class of organic compounds known as phenylpiperidines.

Glutethimide
Duration:

A hypnotic sedative that was introduced in 1954, as a "safe" alternative to barbiturates to treat insomnia. Anecdotally long term use has had effects similar to withdrawal, while still on a stable dose of the drug.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
All ROAs:30-45 minutes2-8 hours1-12 hours
Glutethimide Duration
Avoid:
All other CNS depressants.

Glutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similar withdrawal symptoms. Manufacturing of the drug was discontinued in the US in 1993 and discontinued in several eastern European countries in 2006.

When glutethimide is taken with codeine it enables the body to convert higher amounts of the codeine to morphine. The general sedative effect of the glutethimide also adds to the effect of the combination. It produces an intense, long lasting euphoria similar to heroin use. Quite a few deaths have occurred from abuse of this combination.

  
Glutethimide/Selected Anticoagulants (Vitamin K antagonists) Interactions - Consult your healthcare professional before taking or discontinuing any drug or commencing any course ... and increase your risk for blood clots. If glutethimide is stopped, there is an increased ...
Thursday April 12, 2018 - webmd.com

  
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