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Created Apr 2019 | Updated Oct 2020


  • [RIZE]
  • [CLOZAN]

DEA CODE 2752: Schedule 4

Clotiazepam is a compound of the benzodiazepine class. The drug was developed in Japan and approved for the treatment of insomnia, anxiety and before anesthesia. Clotiazepam was marketed worldwide under different names, however, currently it is available only in South America under the name Neuroval and presumably in Japan. Clotiazepam exerts its action by binding and activating GABA-A receptors.

RouteOnsetDurationAfter Effects
Tripsit Factsheets
All ROAs:10-30 minutes4-8 hours4-8 hours
Clotiazepam Duration
  • clozan
  • distensan
  • trecalmo
  • rize
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  • veratran

It is a benzodiazepine derivative, not approved for sale in the U.S. or Canada, but has been approved in the U.K. Clotiazepam acts at the benzodiazepine receptors. This compound belongs to the class of organic compounds known as thienodiazepines. Clotiazepam is only found in individuals that have used or taken this drug.

It possesses anxiolytic, skeletal muscle relaxant, anticonvulsant, sedative properties. Stage 2 NREM sleep is significantly increased by clotiazepam. Found to be effective in the short-term management of anxiety. Clotiazepam is also used as a premedicant in minor surgery in France and Japan.

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