Barbital, one of the series of barbiturates, has hypnotic, sedative, and anticonvulsant properties and used under the trade name Veronal. It calmed manic patients and helped melancholic patients to sleep and was an effective inducer of sleep in insomniacs, but at the same time compound could induced dependence. It was substituted by the butyl analog, butobarbital, which was three times stronger and its period of action was much shorter due to its lipophilicity.
Veronal is the trade name for a barbiturate drug used to treat mental illness. Veronal was the first commercially available barbiturate, sold from 1903 onwards, and was named after the Italian city of Verona. Barbiturates were used to induce sleep by suppressing brain function and were also used as a hypnotic. They were popular up to the 1950s and were an improvement on their predecessors as the side effects were less severe - although unfortunately they could be extremely addictive. Barbiturates are only available on prescription.
In 1903, doctors synthesised the first diethybarbituric acid, hailing it as an "infallible cure for insomnia". Billed as safe and non- addictive, it was an immediate success in Europe. The overdoses and deaths then began.
At the time of World War One, veronal was probably best known to New Zealanders as the name of a prominent racehorse. Then a young woman named Annie Travin overdosed in Gisborne, the first known local case. Her hospitalisation came as a wealthy gay aristocrat named Hugh Eric Trevanion died in London of veronal poisoning. Scandal sheet NZ Truth wrote of Trevanion: "he was exceedingly effeminate and lisped like a girl ... he wore a kimono and white kid shoes with high heels in the house".
During the 1920s, local veronal use accelerated. Though a doctor's prescription was officially required, an inquest into the death of an Auckland woman heard "the tablets could be bought from a chemist like a bag of lollies. Many people considered veronal tablets on a par with aspirins." So many deaths were linked to the drug by 1930 that the New Zealand authorities added it to the prohibited poisons list, along with morphine and cocaine.
Writer Robin Hyde, a sometime user, noted in 1932 "that it had been the cause of so many recent tragedies that the & New Zealand Pharmacy Board is moving in this direction. Every chemist in New Zealand has reason to know and & fear the effects of veronal when it is rashly used, or administered by people who do not realize its deadly power.
- Barbital was the first commercially available barbiturate
- It was first synthesized in 1902
- It was used as a sleeping aid (hypnotic) from 1903 until the mid-1950s
- Barbital was marketed in 1904 by the Bayer company as Veronal
- A soluble salt of barbital was marketed by the Schering company as Medinal.
The chemical names for barbital are diethylmalonyl urea or diethylbarbituric acid; hence, the sodium salt (known as medinal, a genericised trademark in the United Kingdom) is known also as sodium diethylbarbiturate.
Fatal overdoses of this slow-acting hypnotic were not uncommon
What should I Know Regarding Pregnancy, Nursing and Administering Sodium Barbital to Children or the Elderly? - management or monitoring precaution: Monitor for drug-induced hypothermia, excitement, confusion, and depression. Selected from data included with permission and copyrighted by First Databank ...
Monday June 14, 2021 - webmd.com
How to Take Amobarbital and Dose of Amobarbital - Avoid long-term use of this medication; otherwise patient may get addicted to this drug. Avoid rapid administration; otherwise it may lead to breathing problem. Difficulty in initiating and ...
Amobarbital : Interaction with Food, Herbs, Alcohol and Caffeine - Interaction of Amobarbital with Food, Herbs, Alcohol and Caffeine - For your own safety It is important to understand and avoid the drug-food interaction and how to take the medication.
What should I Know Regarding Pregnancy, Nursing and Administering Barbital Sodium to Children or the Elderly? - management or monitoring precaution: Monitor for drug-induced hypothermia, excitement, confusion, and depression.
|Depressants | Link to this page|